Abstract
From the ether soluble alkaloidal fraction ofPanax ginseng, 4-methyl-5-thiazoleethanol, norharman and harman were isolated. 4-Methyl-5-thiazoleethanol was isolated for the first time from natural resources.
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Han, B.H., Park, M.H., Han, Y.N. and Woo, L.K.: Alakaloidal components ofPanax ginseng.Arch. Pharm. Res. 9, 21 (1986).
Park, J.D., Kim, M.W., Yoo, S.J. and Wee, J.J.: Chemical studies on the ether-soluble alkaloidal fraction ofPanax ginseng. Isolation of 1-carbobutoxy-β-carboline and 1-carbomethoxy-β-carboline.Arch. Pharm. Res. 10, 197 (1987).
Park, J.D., Wee, J.J., Kim, M.W. and Yoo, S.J.: Chemical studies on the alkaloidal fraction ofPanax ginseng C.A. Meyer(I). TLC analysis of various ginsengs and identification of an alkaloid component.Korean J. Ginseng Sci. 11, 17 (1987).
Joshi, B.S., Kamat, V.N. and Gawad, D.H.: Some β-carboline alkaloids ofAilanthus malabaric D.C.Heterocycles 7, 193 (1977).
Pretsch, E., Seibl, J., Simon, W. and Clerc, T.: Tables of spectral data for structure determination of organic compounds, Springer-Verlag Berlin Heidelberg, H270 (1983).
Clarke, G.M., Grigg, R. and Williams, D.H.: Studies in mass spectrometry. Part VII. Mass spectra of thiazoles.J. Chem. Soc. (B), 339 (1966).
Pouchert, D.J. and Campbell, J.R.: “The Aldrich Library of NMR Spectra”, U.S. Aldrich Chemical Company,2, 511 (1983).
Coutts, R.T., Locock, R.A. and Slywka, G.W.A.: Mass spectra of selected β-carbolines,Organic Mass Spectrometry 3, 879 (1970).
Chang, Y.K., Kim, S.Y. and Han, B.H.: Chemical studies on the alkaloidal constituents ofCodonopsis lanceolata, Yakhak Hoeji 30, 1 (1986).
Han, B.H., Park, J.H., Park, M.H. and Han, Y.N.: β-Carboline alkaloids ofpolygala tenuifolia.Arch. Pharm. Res. 8, 243 (1985).
Sakai, S.I., Aimi, N., Takahashi, K., Kitagawa, H., Yamaguchi, K. and Haginiwa, J.: Studies of plants containing indole alkaloids. (4). Alkaloids inOchrosia nakaiana koidz.Yakugaku Zasshi 94, 1274 (1974).
Ho, B.T., Mcisaac, W.M., Walker, K.E. and Estevez, V.: Inhibitors of monoamine oxidase. Influence of methyl substitution on the inhibitory activity of β-carbolines.J. Pharm. Sci. 57, 269 (1968).
Levitt, R.C., Legraverend, C., Nebert, D.W. and Pelkonen, O.: Effects of harman and norharman of the mutagenicity and binding to DNA of Benzo[a]-pyrene metabolitesin vitro and on aryl hydrocarbon hydroxylase induction in cell culture.Biochem. Biophys. Res. Commun. 79, 1167 (1977).
Jeffreys, J.A.D.: The alkaloids of perennial ryegrass (Lolium perenne L.). Part IV. Isolation of a new base, perlolyrine; The crystal structure of its hydrobromide dihydrate, and the synthesis of the base,J. Chem. Soc. C), 1091 (1970).
Han, B.H., Park, J.H., Park, M.H. and Han, Y.N.: Studies on the alkaloidal components of the fruits ofLycium chinense.Arch. Pharm. Res. 8, 249 (1985).
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Park, J.D., Kim, M.W., Yoo, S.J. et al. A thiazole and two β-carboline constitutents fromPanax ginseng . Arch. Pharm. Res. 11, 52–55 (1988). https://doi.org/10.1007/BF02884768
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DOI: https://doi.org/10.1007/BF02884768