Abstract
The cellular localization and specific expression of TR3 mRNA in rat testis were investigated by the method of immuno- histochemistry andin situ hybridization. It was demonstrated that orphan receptor TR3 was expressed in a significant amount in rat testis and TR3 protein and mRNA were specifically localized in germ cells, suggesting that TR3 may have an important function in regulating rat germ cell development.
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Tsai, M. J., O’Malley, B. W., Molecular mechanism of action of steroid/thyroid receptor superfamily members,Annu. Rev. Biochem., 1994, 63: 451.
Hazel, G. F., Nathans, D., Lau, L. F., A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily,Proc. Natl. Acad. Sci. USA, 1988, 85: 8444.
Willams, G. T., Lau, L. F., Activation of the inducible orphan receptor gene Nur 77 by serum growth factor: dissociation of immediate early and delayed-early response,Mol. Cell Biol., 1993, 13: 6124.
Davis, I. J., Lau, L. F., Endocrine and neurogenic regulation of the orphan receptor gene Nur 77 and Nurr-1 in the adrenal glands,Mol. Cell Biol., 1994, 14: 3469.
Lee, S. L., Wesselschmidt, R. L., Linette, G. P.et al., Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFIB (Nur 77).Science, 1995, 269: 532.
Woronicz, J. D., Calnan, B., Ngo, V.et al., Requirement for the orphan steroid receptor Nur 77 in apoptosis of T cell hybridomas,Nature, 1994, 367: 277.
Grawford, P. A., Sadovsky, Y., Woodson, K.et al., Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFIB-deficient mice,Mol. Cell Biol., 1995, 15: 4331.
Wilson, T., Mouw, A. R., Weaver, C. A.et al., The orphan receptor NGFIB regulates expression of the gene encoding steroid 21-hydroxylase,Mol. Cell Biol., 1993, 13: 861.
Lin, H. H., Tu, Z. J., Ann, D. K., Involvement of nuclear orphan receptor NGFI-B in transcriptional activation of salivary-specific R 15 gene by cAMP,J. Biol. Chem., 1996, 271: 27637.
Paulsen, R. E., Weaver, C. A., Fahrner, T. J.et al., Domain regulating transcriptional activity of the inducible orphan receptor NGFIB,J. Biol. Chem., 1992, 267: 16491.
Zhou, H. M., Liu, Y. X., Localization of tissue-type plasminogen activator (tPA) and plasminogen activator inhibitor (PAI-1) messenger RNA (mRNA) in rat testis,Chinese Sci. Bull. (in Chinese), 1996, 41(5): 455.
Zhou, H. M., Zhang, T., Liu, Y. X., Expression of LHR in rat epididymis,Chinese Sci. Bull. (in Chinese), 1996, 41 (17): 1608.
Kelwyn, T., Jesus, D. M., Pam, E.et al., Developmental regulation of expression of the lactate dehydrogenase (LDH) multigene family during mouse spermatogenesis,Development, 1990, 109: 483.
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Mu, X., Liu, Y. Localization and expression of TR3 orphan receptor protein and its mRNA in rat. Chin. Sci. Bull. 43, 146–149 (1998). https://doi.org/10.1007/BF02883930
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DOI: https://doi.org/10.1007/BF02883930