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Inhibition of the incorporation of14C-precursors inMycobacterium smegmatis by antibiotics and chemotherapeutics

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Abstract

Twenty antituberculostatics and twelve other compounds were divided into three groups according to their ability to influence the rate of incorporation of14C-adenine and14C-leucine inM. smegmatis. The first group includes compounds significantly inhibiting the incorporation of14C-leucine, the second group comprises compounds inhibiting simultaneously the incorporation of both14C-precursors, the third group contains compounds that do not bring about a 50% decrease of the rate of incorporation even at a concentration of 400 μg/mL.

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Majtán, V., Drobnica, L. Inhibition of the incorporation of14C-precursors inMycobacterium smegmatis by antibiotics and chemotherapeutics. Folia Microbiol 27, 43–48 (1982). https://doi.org/10.1007/BF02883837

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