Abstract
The influence of La3+ on lactate dehydrogenase catalysis was investigated by electrochemical and FT-Raman techniques. The results showed that La3+ ions bind preferably with phosphate moiety and ribose group (3′-OH) connected to nicotinamide in coenzyme NAD+/NADH, destabilize the enzyme-coenzyme complex and inhibit LDH activity.
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Wang, X., Xu, Z. & Gao, X. An electrochemical and Raman spectroscopic study on involvement of La3+ ions in lactate dehydrogenase catalysis. Chin. Sci. Bull. 43, 1625–1630 (1998). https://doi.org/10.1007/BF02883407
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DOI: https://doi.org/10.1007/BF02883407