Summary
The capillary syndrome is present in many viral infections and is involved in the inflammatory processes.
Citrus flavonoids, otherwise known as vitamin ‘P’ or capillary permeability factor, minimize the injury to the capillary wall induced by viral infections.
Five cases of virus influenza were treated with citrus flavonoids (C.V.P.) with encouraging results.
The therapeutic effect of flavonoids in viral infections might be interpreted as the result of improved functioning of the capillary system.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Rivers, T. M.: Filtrable Viruses with Particular Reference to Psittacosis. The Harvey Lectures, Series XXIX, 220–224, 1933–34.
Eppinger, H.: Hypoalbuminemia and the Capillary Syndrome. Verh. dtsch. Ges. Kreistaufforsch. 11 Meeting, 166, 1938.
Danielli, J. F. and Stock, A.: The Mechanism of Capillary Permeability. Biol. Rev., Cambridge Phil. Soc, 19:81, 1949.
Lyon, Ernst: The Capillary Syndrome in Viral Disease. Cardiologia, 24:143, 1954.
Lucke, B. and Mallory, T.: The Fulminant Form of Epidemic Hepatitis. Am. J. Path., 22:867, 1946.
Bodian, D. and Howe, H. A.: Neuropies and the Genesis of Cerebral Lesions in Poliomyelitis: An Experimental Study. Bull. Johns Hopkins Hosp., 68:58, 1941.
Bower, A. S., Eaton, R. W., Chadhoff, J. S., Affeldt, J. E. and Chaney: Poliomyelitis. Am. J. Med. Sci., 222:46, 1950.
Letterer. E.: Experimental Edema and Capillary Permeability. Dtsch. med. Wsc.hr., 78:425, 1953.
Wolman, E.: Smallpox. Am. J. Clin. Path., 21:1127, 1951.
Svertson, S. E. and Hyman, I. B.: Edema in Smallpox. U. S. Army Forces Med. J., 3:1777, 1951.
Miller, A. A.: Purpura in the Course of Measles. Brit. J. Child. Dis., 38:1, 1941.
Rake, Geoffrey: Measles. Viral and Rickettsial Infections of Man. Lippincott & Company, 1952.
Horstall, Frank L.: Primary Atypical Pneumonia. Ibid.
Enders, John F.: Mumps. Ibid.
Scott, T. F. M., Steigman, A. J. and Convey, J.: Acute Infectious Gingivostomatitis. J.A.M.A., 117:999, 1941.
Brightman, I. J.: Recovery of a Filtrable Virus from Children with Influenza. Am. J. Dis. Child., 52:78, 1936.
Olitzky, Peter E.: Viral Encephalitides. Viral and Rickettsial Infections of Man, Lippincott & Company, 1952.
Armentano, L., Bentsath, A., Beres, T., Rusznyak, St. and Szent-Gyorgyi, A.: On the Influence of Substances of the Flavone Group on the Permeability of Capillaries; Vitamin P. Dtsch. med. Wchschr., 62:1325, 1936.
Bacharach, A. L., Coates, M. E. and Middleton, T. R.: A Biological Test for Vitamin P Activity. Biochem. J., 36:27, 1936.
Scarborough, Harold: Vitamin P. Biochem. J., 39:271, 1945.
Griffith, J. Q. and Lindauer, M. A.: Increased Capillary Fragility in Hypertension. Am. Heart J., 28:758, 1944.
Sokoloff, B., Eddy, W. H. and Redd, J.: The Biological Activity of a Flavonoid (Vitamin ‘P’) Compound. J. Clin. Invest., 30:395, 1951.
Sokoloff, B. and Eddy, W. H.: Bio-Flavonoids in Capillary Fragility. Mono. Ser. 2, Capillary Fragility and Stress, Florida Southern College, 1952.
Puig-Muset, R.: Introductional Estudio de la Vitamin P. Barcelona, 1945.
Sokoloff, B. and Redd, J.: Studies on Vitamin P. Capillary Permeability and Fragility, Mono. 1, Florida Southern College, 1949.
McKeen, C. D.: Inhibition of Virus Infections of Certain Plants by Extracts fromCapsicum Frutescens. Science, 120:229, 1954.
Biskind, Morton S. and Martin, William Coda: The Use of Citrus Flavonoids in Respiratory Infections. Am. J. Dig. Dis., 21:177, 1954.
Author information
Authors and Affiliations
Additional information
Aided by a grant from The Marcia Tucker Foundation.
Rights and permissions
About this article
Cite this article
Sokoloff, B. The capillary syndrome in viral infections: Treatment with citrus flavonoids. Amer. Jour. Dig. Dis. 22, 7–9 (1955). https://doi.org/10.1007/BF02881509
Issue Date:
DOI: https://doi.org/10.1007/BF02881509