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Pathogenesis Of pancreatitis—Experimental and cyto-chemical studies

  • Published:
The American Journal of Digestive Diseases

Summary

  1. 1)

    Our experiments prove that there are many etiological factors in the acute pancreatitis and that all of them act by way of the same physiopathogenic mechanism.

  2. 2)

    The cytochemical investigation with the method of MeManus demonstrates that the initial lesion is found in the connective not in the parenchymatous tissue. The oedema of the gland is not produced by the pancreatic extraductary secretion, but by vascular alterations. These conduce to plasma transudation demonstrated by the presence of fibrin or “fibrinoid” substance within the blood vessels and among the acini.

  3. 3)

    We propose the treatment by the intravenous injection (1–2 grs.) of procaine per day in saline plasma or whole blood.

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Authors and Affiliations

  1. Córdoba, Argentina

    Orlando F. Longo, Carlos A. Sosa-Gallardo & Oscar N. Pessat

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  1. Orlando F. Longo
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  2. Carlos A. Sosa-Gallardo
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  3. Oscar N. Pessat
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Orlando, F.L., Carlos, A.SG. & Oscar, N.P. Pathogenesis Of pancreatitis—Experimental and cyto-chemical studies. Amer. Jour. Dig. Dis. 21, 100–102 (1954). https://doi.org/10.1007/BF02881144

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