Summary
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1.
The lipotropic activity of betaine was studied in a series of patients suffering from proven coronary atherosclerosis.
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2.
All patients had previously been treated with low fat-low cholesterol diets and other lipotropic agents for periods up to six years. A baseline for clinical and biochemical evaluation was thus established.
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3.
The clinical and biochemical results obtained indicate that betaine is the best tolerated and most effective lipotropic agent heretofore studied.
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4.
Clinical results showed striking improvement in well-being, gain of appetite, increase in energy, increase in exercise tolerance and decrease in cardiac pain.
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5.
Biochemical results indicated uniform and significant falls in serum total cholesterol and consistent rises in serum phospholipid-cholesterol ratios.
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Morrison, L.M. Results of betaine treatment of Atherosclerosis. Amer. Jour. Dig. Dis. 19, 381–384 (1952). https://doi.org/10.1007/BF02881126
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DOI: https://doi.org/10.1007/BF02881126