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Macrophages in immunobiology

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Ricerca in clinica e in laboratorio

Summary

Macrophages are now known to be important not only in resistance to infection but also in immunoregulation, in resistance to tumours and as secretory cells. Among problems requiring further investigation are the ways in which they destroy intracellular organisms, the ways in which they recognize and destroy tumour cells and the extent of their heterogeneity.

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References

  1. Alexander P.: Surveillance against Neoplastic Cells: Is it Mediated by Macrophages? — Brit. J. Cancer33, 344, 1976.

    PubMed  CAS  Google Scholar 

  2. Baldwin R. W.: Role of Immunosurveillance against Chemically Induced Rat Tumours — Transplant. Rev.28, 62, 1976.

    PubMed  CAS  Google Scholar 

  3. Basten A., Howard J. G.: Thymus Independence — Contemp. Top. Immunobiol.2, 265, 1973.

    CAS  Google Scholar 

  4. Basten A., Mitchell J.: Role of Macrophages in T Cell-B Cell Collaboration in Antibody Production — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 45.

    Google Scholar 

  5. Benacerraf B., Katz D. H.: The Histocompatibility-Linked Immune Response Genes — Advanc. Cancer Res.21, 121, 1975.

    CAS  Google Scholar 

  6. Blanden R. V.: Modification of Macrophage Function — J. reticuloendoth. Soc.5, 179, 1968.

    CAS  Google Scholar 

  7. Blanden R. V., Hapel A. J., Doherty P. C., Zinkernagel R. M.: Lymphocyte-Macrophage Interactions and Macrophage Activation in the Expression of Antimicrobial Immunityin Vivo — In:Nelson D.S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 367.

    Google Scholar 

  8. Bray M. A., Gordon D., Morley J.: Role of Prostaglandins in Reactions of Cellular Immunity — Brit. J. Pharmacol.52, 453P, 1974.

  9. Bretscher P. A.: The Two Signal Model for B Cell Induction — Transplant. Rev.23, 37, 1975.

    PubMed  CAS  Google Scholar 

  10. Bullock W. E., Jr.: Perturbation of Lymphocyte Circulation in Experimental Murine Leprosy. I. Description of the Defect — J. Immunol.117, 1164, 1976.

    PubMed  Google Scholar 

  11. Bullock W. E., Jr.: Perturbation of Lymphocyte Circulation in Experimental Murine Leprosy. II. Nature of the Defect — J. Immunol.117, 1171, 1976.

    PubMed  Google Scholar 

  12. Carr I.: The Macrophage: A Review of Ultrastructure and Function — Academic Press, London, 1973.

    Google Scholar 

  13. Cerottini J.-C., Brunner K. J.: Cell-Mediated Cytotoxicity, Allograft Rejection, and Tumor Immunity — Advanc. Immunol.18, 67, 1974.

    Article  CAS  Google Scholar 

  14. Claman H. N., Mosier D. E.: Cell-Cell Interactions in Antibody Production — Progr. Allergy16, 40, 1972.

    CAS  Google Scholar 

  15. Cohn Z. A.: The Structure and Function of Monocytes and Macrophages — Advanc. Immunol.9, 163, 1968.

    CAS  Google Scholar 

  16. Cohn M.: Summary Discussion of Directions of Immunobiology — In:Oppenheim J. J., Rosenstreich D. L. (Eds): Mitogens in Immunobiology. Academic Press, New York, 1976; p. 663.

    Google Scholar 

  17. Cohn M., Blomberg B.: The Self-Nonself Discrimination: A One- or Two-Signal Mechanism — Scand. J. Immunol.4, 1, 1975.

    Article  PubMed  CAS  Google Scholar 

  18. Coutinho A.: The Theory of the ‘One Nonspecific Signal’ Model for B Cell Activation — Transplant. Rev.23, 49, 1975.

    PubMed  CAS  Google Scholar 

  19. Dannenberg A. M.: Cellular Hypersensitivity and Cellular Immunity in the Pathogenesis of Tuberculosis: Specificity, Systemic and Local Nature, and Associated Macrophage Enzymes — Bact. Rev.21, 85, 1968.

    Google Scholar 

  20. Dannenberg A. M.: Macrophages in Inflammation and Infection — New Engl. J. Med.293, 489, 1975.

    PubMed  Google Scholar 

  21. David J. R., Remold H. G.: Macrophage Activation by Lymphocyte Mediators and Studies on the Interaction of Macrophage Inhibitory Factor (MIF) with Its Target Cell — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 401.

    Google Scholar 

  22. Davies P., Allison A. C.: Secretion of Macrophage Enzymes in Relation to the Pathogenesis of Chronic Inflammation — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 427.

    Google Scholar 

  23. Doherty P. C., Zinkernagel R. M.: H-2 Compatibility Is Required for T-Cell Mediated Lysis of Target Cells Infected with Lymphocytic Choriomeningitis Virus — J. exp. Med.141, 502, 1975.

    Article  PubMed  CAS  Google Scholar 

  24. Erb P., Feldmann M.: The Role of Macrophages in the Generation of Helper T Cells. II. The Genetic Control of the Macrophage-T-Cell Interaction for Helper Cell Induction with Soluble Antigens — J. exp. Med.142, 460, 1975.

    Article  PubMed  CAS  Google Scholar 

  25. Erb P., Feldmann M.: The Role of Macrophages in the Generation of T Helper Cells. III. Influence of Macrophage-Derived Factors in Helper Cell Induction — Europ. J. Immunol.5, 759, 1975.

    Article  CAS  Google Scholar 

  26. Erb P., Feldmann M., Hogg N.: The Role of Macrophages in the Generation of Helper T Cells. IV. Nature of Genetically Related Factor Derived from Macrophages Incubated with Soluble Antigens — Europ. J. Immunol.6, 365, 1976.

    Article  CAS  Google Scholar 

  27. Erb P., Meier B., Feldmann M.: Two-Gene Control of T-Helper Cell Induction — Nature (Lond.)263, 601, 1976.

    Article  CAS  Google Scholar 

  28. Evans R., Alexander P.: Mechanisms of Immunologically Specific Killing of Tumour Cells by Macrophages — Nature (Lond.)236, 168, 1972.

    Article  CAS  Google Scholar 

  29. Evans R., Alexander P.: Mechanisms of Extracellular Killing of Nucleated Mammalian Cells by Macrophages — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 535.

    Google Scholar 

  30. Fernbach B. R., Kirchner H., Herberman R. B.: Inhibition of the Mixed Lymphocyte Culture by Peritoneal Exudate Cells — Cell. Immunol.22, 399, 1976.

    Article  PubMed  CAS  Google Scholar 

  31. Gery I., Waksman B. H.: Potentiation of the T-Lymphocyte Response to Mitogens. II. The Cellular Source of Potentiating Mediators — J. exp. Med.136, 143, 1972.

    Article  PubMed  CAS  Google Scholar 

  32. Gordon D., Bray M. A., Morley J.: Control of Lymphokine Secretion by Prostaglandins — Nature (Lond.)262, 401, 1976.

    Article  CAS  Google Scholar 

  33. Gordon S., Unkeless J. C., Cohn Z. A.: The Macrophage as Secretory Cell — In:Rosenthal A. S. (Ed.): Immune Recognition. Academic Press, New York, 1975; p. 589.

    Google Scholar 

  34. Gorer P. A.: Some Recent Work on Tumor Immunity — Advanc. Cancer Res.4, 149, 1956.

    Article  CAS  Google Scholar 

  35. Granger G. A., Weiser R. S.: Homograft Target Cells; Specific Destructionin Vitro by Contact Interaction with Immune Macrophages — Science145, 1427, 1964.

    Article  PubMed  CAS  Google Scholar 

  36. Hibbs J. B., Jr.: Discrimination between Neoplastic and Non-Neoplastic Cellsin Vitro by Activated Macrophages — J. nat. Cancer Inst.53, 1487, 1974.

    PubMed  Google Scholar 

  37. Hibbs J. B., Jr.: Activated Macrophages as Cytotoxic Effector Cells. I. Inhibition of Specific and Nonspecific Tumor Resistance by Trypan Blue — Transplantation19, 77, 1975.

    Article  PubMed  CAS  Google Scholar 

  38. Hibbs J. B., Jr.,Lambert L. H., Jr.,Remington J. S.: Possible Role of Macrophage-Mediated Nonspecific Cytotoxicity in Tumour Resistance — Nature (New Biol.)235, 48, 1972.

    Google Scholar 

  39. Hirsch J. G.: Immunity to Infectious Diseases: Review of Some Concepts of Metchnikoff — Bact. Rev.23, 48, 1959.

    PubMed  CAS  Google Scholar 

  40. Hoessli D. S., Waksman B. H.: Present Status of Research on Lymphocyte Activating Factor (LAF) — In:Oppenheim J. J., Rosenstreich D. L. (Eds): Mitogens in Immunobiology. Academic Press, New York, 1976; p. 385.

    Google Scholar 

  41. Hoy W. E., Nelson D. S.: Studies on Cytophilic Antibodies. V. Alloantibodies Cytophilic for Mouse Macrophages — Aust. J. exp. Biol. med. Sci.47, 525, 1969.

    Article  PubMed  CAS  Google Scholar 

  42. Keller R.: Cytostatic Elimination of Syngeneic Rat Tumor Cellsin Vitro by Nonspecifically Activated Macrophages — J. exp. Med.138, 625, 1973.

    Article  PubMed  CAS  Google Scholar 

  43. Keller R.: Cytostatic and Cytocidal Effects of Activated Macrophages — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 487.

    Google Scholar 

  44. Lemke H., Coutinho A., Opitz H. G., Gronowicz E.: Macrophages Suppress Direct B-Cell Activation by Lipopolysaccharide — Scand. J. Immunol.4, 707, 1975.

    Article  PubMed  CAS  Google Scholar 

  45. Liew F. Y., Parish C. R.: Regulation of the Immune Response by Antibody. III. The Effect of Macrophage Cytophilic Antibody on Humoral and Cell-Mediated Immunity — Cell. Immunol.5, 520, 1972.

    Article  PubMed  CAS  Google Scholar 

  46. Lohmann-Matthes M.-L.: Induction of Macrophage-Mediated Cytotoxicity — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 463.

    Google Scholar 

  47. Lonai P., Feldmann M.: Studies on the Effect of Macrophages in anin Vitro Graft Reaction System — Immunology21, 861, 1971.

    PubMed  CAS  Google Scholar 

  48. Mackaness G. B.: The Immunological Basis of Acquired Cellular Resistance — J. exp. Med.120, 105, 1964.

    Article  PubMed  CAS  Google Scholar 

  49. Mackaness G. B.: The Influence of Immunologically Committed Lymphoid Cells on Macrophage Activityin Vivo — J. exp. Med.129, 973, 1969.

    Article  PubMed  CAS  Google Scholar 

  50. Metchnikoff E.: Lectures on the Comparative Pathology of Inflammation — Kegan, Paul, Trench, Trumber and Co., London, 1893.

    Google Scholar 

  51. Metchnikoff E.: Immunity in Infectious Diseases — Cambridge University Press, Cambridge, 1905.

    Google Scholar 

  52. Miller C. L., Mishell R. I.: Differential Regulatory Effects of Accessory Cells on the Generation of Cell-Mediated Immune Reactions — J. Immunol.114, 692, 1975.

    PubMed  CAS  Google Scholar 

  53. Miller J. F. A. P., Vadas M. A., Whitelaw A., Gamble J.: H-2 Gene Complex Restricts Transfer of Delayed-Type Hypersensitivity in Mice — Proc. nat. Acad. Sci. (Wash.)72, 5095, 1975.

    Article  CAS  Google Scholar 

  54. Miller J. F. A. P., Vadas M. A., Whitelaw A., Gamble J.: Role of Major Histocompatibility Complex Gene Products in Delayed-Type Hypersensitivity — Proc. nat. Acad. Sci. (Wash.)73, 2486, 1976.

    Article  CAS  Google Scholar 

  55. Mitchell G. F.: A Proposal that Onein Vivo Function of T Cells Is to Regulate the Availability of Antigen for B Cells — Transplant. Rev.23, 119, 1975.

    PubMed  CAS  Google Scholar 

  56. Möller G., Coutinho A., Gronowicz E., Hammarström L., Smith E.: Role of Mitogenic Components of Thymus-Independent Antigens — In:Oppenheim J. J., Rosenstreich D. L. (Eds): Mitogens in Immunobiology. Academic Press, New York, 1976; p. 291.

    Google Scholar 

  57. Mosier D. E.: The Role of Macrophages in the Specific Determination of Immunogenicity and Tolerogenicity — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 35.

    Google Scholar 

  58. Nathan C. F., Hill V. M., Terry W. D.: Isolation of a Subpopulation of Adherent Peritoneal Cells with Anti-Tumour Activity — Nature (Lond.)260, 146, 1976.

    Article  CAS  Google Scholar 

  59. Nelson D. S.: Macrophages and Immunity — North-Holland, Amsterdam, 1969.

    Google Scholar 

  60. Nelson D. S.: Macrophages as Effectors of Cell-Mediated Immunity — CRC Crit. Rev. Microbiol.1, 353, 1972.

    Article  Google Scholar 

  61. Nelson D. S.: Nonspecific Immunoregulation by Macrophages and Their Products — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 235.

    Google Scholar 

  62. Nelson D. S.: Inhibition of Lymphocyte Transformation by Products of Macrophages and Other Cells — In:Oppenheim J. J., Rosenstreich D. L. (Eds): Mitogens in Immunobiology. Academic Press, New York, 1976; p. 477.

    Google Scholar 

  63. Nelson D. S., Hopper K. E., Nelson M.: Role of the Macrophage in Resistance to Cancer — In:Waters H. (Ed.): The Handbook of Cancer and Immunology. Garland, New York, 1977. (In Press).

    Google Scholar 

  64. Nelson D. S., Nelson M., Hopper K. E., Blanden R. V., Gardner I. D., Bowern N., Kearney R.: Possible Basis of the Immunological Success of Some Tumours — (In Preparation).

  65. North R. J.: Importance of Thymus-Derived Lymphocytes in Cell-Mediated Immunity to Infection — Cell. Immunol.7, 166, 1973.

    Article  PubMed  CAS  Google Scholar 

  66. Nossal G. J. V., Schrader J. W.: B Lymphocyte-Antigen Interactions in the Initiation of Tolerance or Immunity — Transplant. Rev.23, 138, 1975.

    PubMed  CAS  Google Scholar 

  67. Oliver J. M., Berlin R. D.: Macrophage Membranes — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 259.

    Google Scholar 

  68. Oppenheim J. J., Seeger R. C.: The Role of Macrophages in the Induction of Cell-Mediated Immunityin Vivo — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 111.

    Google Scholar 

  69. Pearsall N. W., Weiser R. S.: The Macrophage — Lea and Febiger, Philadelphia, 1970.

    Google Scholar 

  70. Pierce C. W., Kapp J. A.: The Role of Macrophages in Antibody Responsesin Vitro — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 1.

    Google Scholar 

  71. Rosenstreich D. L.: The Macrophage Requirement for Mitogenic Activation of T-Lymphocytes — In:Oppenheim J. J., Rosenstreich D. L. (Eds.): Mitogens in Immunobiology. Academic Press, New York, 1976; p. 385.

    Google Scholar 

  72. Rosenthal A. S., Blake J. T., Ellner J. J., Greineder D. K., Lipsky P. E.: Macrophage Function in Antigen Recognition by T Lymphocytes — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 131.

    Google Scholar 

  73. Schimpl A., Wecker E.: A Third Signal in B Cell Activation Given by TRF — Transplant. Rev.23, 176, 1976.

    Google Scholar 

  74. Schorlemmer H. J., Allison A. C.: Effects of Activated Complement Components on Enzyme Secretion by Macrophages — Immunology31, 781, 1976.

    PubMed  CAS  Google Scholar 

  75. Seeger R. C., Oppenheim J. J.: Macrophage-Bound Antigens. II. Comparison of the Immunogenicity of Antigens Bound to Macrophages, Lymphocytes, Thymocytes and Hepatoma Cells — J. Immunol.109, 255, 1972.

    PubMed  CAS  Google Scholar 

  76. Stuart A. E.: The Reticulo-Endothelial System — Livingston, Edinburgh, 1970.

    Google Scholar 

  77. van Furth R. (Ed.): Mononuclear Phagocytes — Blackwell, Oxford, 1970.

    Google Scholar 

  78. van Furth R., Cohn Z. A., Hirsch J. G., Humphrey J. H., Spector W. G., Langevoort H. L.: The Mononuclear Phagocytic System: A New Classification of Macrophages, Monocytes, and Their Precursor Cells — Bull. Wld. Hlth Org.46, 845, 1972.

    Google Scholar 

  79. Wagner H., Feldmann M., Boyle W., Schrader J. W.: Cell-Mediated Immune Responsein Vitro. III. The Requirement for Macrophages in Cytotoxic Reactions against Cell-Bound and Subcellular Alloantigens — J. exp. Med.136, 331, 1972.

    Article  PubMed  CAS  Google Scholar 

  80. Walker W. S.: Functional Heterogeneity of Macrophages — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 91.

    Google Scholar 

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The work of the author’s laboratory is supported by grants from the National Health and Medical Research Council, the New South Wales State Cancer Council and the Australian Kidney Foundation. It is carried out in part pursuant to Research Contract N01-CB-63973 with the United States National Cancer Institute.

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Nelson, D.S. Macrophages in immunobiology. La Ricerca Clin. Lab. 7, 93–101 (1977). https://doi.org/10.1007/BF02879475

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