Summary
Macrophages are now known to be important not only in resistance to infection but also in immunoregulation, in resistance to tumours and as secretory cells. Among problems requiring further investigation are the ways in which they destroy intracellular organisms, the ways in which they recognize and destroy tumour cells and the extent of their heterogeneity.
References
Alexander P.: Surveillance against Neoplastic Cells: Is it Mediated by Macrophages? — Brit. J. Cancer33, 344, 1976.
Baldwin R. W.: Role of Immunosurveillance against Chemically Induced Rat Tumours — Transplant. Rev.28, 62, 1976.
Basten A., Howard J. G.: Thymus Independence — Contemp. Top. Immunobiol.2, 265, 1973.
Basten A., Mitchell J.: Role of Macrophages in T Cell-B Cell Collaboration in Antibody Production — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 45.
Benacerraf B., Katz D. H.: The Histocompatibility-Linked Immune Response Genes — Advanc. Cancer Res.21, 121, 1975.
Blanden R. V.: Modification of Macrophage Function — J. reticuloendoth. Soc.5, 179, 1968.
Blanden R. V., Hapel A. J., Doherty P. C., Zinkernagel R. M.: Lymphocyte-Macrophage Interactions and Macrophage Activation in the Expression of Antimicrobial Immunityin Vivo — In:Nelson D.S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 367.
Bray M. A., Gordon D., Morley J.: Role of Prostaglandins in Reactions of Cellular Immunity — Brit. J. Pharmacol.52, 453P, 1974.
Bretscher P. A.: The Two Signal Model for B Cell Induction — Transplant. Rev.23, 37, 1975.
Bullock W. E., Jr.: Perturbation of Lymphocyte Circulation in Experimental Murine Leprosy. I. Description of the Defect — J. Immunol.117, 1164, 1976.
Bullock W. E., Jr.: Perturbation of Lymphocyte Circulation in Experimental Murine Leprosy. II. Nature of the Defect — J. Immunol.117, 1171, 1976.
Carr I.: The Macrophage: A Review of Ultrastructure and Function — Academic Press, London, 1973.
Cerottini J.-C., Brunner K. J.: Cell-Mediated Cytotoxicity, Allograft Rejection, and Tumor Immunity — Advanc. Immunol.18, 67, 1974.
Claman H. N., Mosier D. E.: Cell-Cell Interactions in Antibody Production — Progr. Allergy16, 40, 1972.
Cohn Z. A.: The Structure and Function of Monocytes and Macrophages — Advanc. Immunol.9, 163, 1968.
Cohn M.: Summary Discussion of Directions of Immunobiology — In:Oppenheim J. J., Rosenstreich D. L. (Eds): Mitogens in Immunobiology. Academic Press, New York, 1976; p. 663.
Cohn M., Blomberg B.: The Self-Nonself Discrimination: A One- or Two-Signal Mechanism — Scand. J. Immunol.4, 1, 1975.
Coutinho A.: The Theory of the ‘One Nonspecific Signal’ Model for B Cell Activation — Transplant. Rev.23, 49, 1975.
Dannenberg A. M.: Cellular Hypersensitivity and Cellular Immunity in the Pathogenesis of Tuberculosis: Specificity, Systemic and Local Nature, and Associated Macrophage Enzymes — Bact. Rev.21, 85, 1968.
Dannenberg A. M.: Macrophages in Inflammation and Infection — New Engl. J. Med.293, 489, 1975.
David J. R., Remold H. G.: Macrophage Activation by Lymphocyte Mediators and Studies on the Interaction of Macrophage Inhibitory Factor (MIF) with Its Target Cell — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 401.
Davies P., Allison A. C.: Secretion of Macrophage Enzymes in Relation to the Pathogenesis of Chronic Inflammation — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 427.
Doherty P. C., Zinkernagel R. M.: H-2 Compatibility Is Required for T-Cell Mediated Lysis of Target Cells Infected with Lymphocytic Choriomeningitis Virus — J. exp. Med.141, 502, 1975.
Erb P., Feldmann M.: The Role of Macrophages in the Generation of Helper T Cells. II. The Genetic Control of the Macrophage-T-Cell Interaction for Helper Cell Induction with Soluble Antigens — J. exp. Med.142, 460, 1975.
Erb P., Feldmann M.: The Role of Macrophages in the Generation of T Helper Cells. III. Influence of Macrophage-Derived Factors in Helper Cell Induction — Europ. J. Immunol.5, 759, 1975.
Erb P., Feldmann M., Hogg N.: The Role of Macrophages in the Generation of Helper T Cells. IV. Nature of Genetically Related Factor Derived from Macrophages Incubated with Soluble Antigens — Europ. J. Immunol.6, 365, 1976.
Erb P., Meier B., Feldmann M.: Two-Gene Control of T-Helper Cell Induction — Nature (Lond.)263, 601, 1976.
Evans R., Alexander P.: Mechanisms of Immunologically Specific Killing of Tumour Cells by Macrophages — Nature (Lond.)236, 168, 1972.
Evans R., Alexander P.: Mechanisms of Extracellular Killing of Nucleated Mammalian Cells by Macrophages — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 535.
Fernbach B. R., Kirchner H., Herberman R. B.: Inhibition of the Mixed Lymphocyte Culture by Peritoneal Exudate Cells — Cell. Immunol.22, 399, 1976.
Gery I., Waksman B. H.: Potentiation of the T-Lymphocyte Response to Mitogens. II. The Cellular Source of Potentiating Mediators — J. exp. Med.136, 143, 1972.
Gordon D., Bray M. A., Morley J.: Control of Lymphokine Secretion by Prostaglandins — Nature (Lond.)262, 401, 1976.
Gordon S., Unkeless J. C., Cohn Z. A.: The Macrophage as Secretory Cell — In:Rosenthal A. S. (Ed.): Immune Recognition. Academic Press, New York, 1975; p. 589.
Gorer P. A.: Some Recent Work on Tumor Immunity — Advanc. Cancer Res.4, 149, 1956.
Granger G. A., Weiser R. S.: Homograft Target Cells; Specific Destructionin Vitro by Contact Interaction with Immune Macrophages — Science145, 1427, 1964.
Hibbs J. B., Jr.: Discrimination between Neoplastic and Non-Neoplastic Cellsin Vitro by Activated Macrophages — J. nat. Cancer Inst.53, 1487, 1974.
Hibbs J. B., Jr.: Activated Macrophages as Cytotoxic Effector Cells. I. Inhibition of Specific and Nonspecific Tumor Resistance by Trypan Blue — Transplantation19, 77, 1975.
Hibbs J. B., Jr.,Lambert L. H., Jr.,Remington J. S.: Possible Role of Macrophage-Mediated Nonspecific Cytotoxicity in Tumour Resistance — Nature (New Biol.)235, 48, 1972.
Hirsch J. G.: Immunity to Infectious Diseases: Review of Some Concepts of Metchnikoff — Bact. Rev.23, 48, 1959.
Hoessli D. S., Waksman B. H.: Present Status of Research on Lymphocyte Activating Factor (LAF) — In:Oppenheim J. J., Rosenstreich D. L. (Eds): Mitogens in Immunobiology. Academic Press, New York, 1976; p. 385.
Hoy W. E., Nelson D. S.: Studies on Cytophilic Antibodies. V. Alloantibodies Cytophilic for Mouse Macrophages — Aust. J. exp. Biol. med. Sci.47, 525, 1969.
Keller R.: Cytostatic Elimination of Syngeneic Rat Tumor Cellsin Vitro by Nonspecifically Activated Macrophages — J. exp. Med.138, 625, 1973.
Keller R.: Cytostatic and Cytocidal Effects of Activated Macrophages — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 487.
Lemke H., Coutinho A., Opitz H. G., Gronowicz E.: Macrophages Suppress Direct B-Cell Activation by Lipopolysaccharide — Scand. J. Immunol.4, 707, 1975.
Liew F. Y., Parish C. R.: Regulation of the Immune Response by Antibody. III. The Effect of Macrophage Cytophilic Antibody on Humoral and Cell-Mediated Immunity — Cell. Immunol.5, 520, 1972.
Lohmann-Matthes M.-L.: Induction of Macrophage-Mediated Cytotoxicity — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 463.
Lonai P., Feldmann M.: Studies on the Effect of Macrophages in anin Vitro Graft Reaction System — Immunology21, 861, 1971.
Mackaness G. B.: The Immunological Basis of Acquired Cellular Resistance — J. exp. Med.120, 105, 1964.
Mackaness G. B.: The Influence of Immunologically Committed Lymphoid Cells on Macrophage Activityin Vivo — J. exp. Med.129, 973, 1969.
Metchnikoff E.: Lectures on the Comparative Pathology of Inflammation — Kegan, Paul, Trench, Trumber and Co., London, 1893.
Metchnikoff E.: Immunity in Infectious Diseases — Cambridge University Press, Cambridge, 1905.
Miller C. L., Mishell R. I.: Differential Regulatory Effects of Accessory Cells on the Generation of Cell-Mediated Immune Reactions — J. Immunol.114, 692, 1975.
Miller J. F. A. P., Vadas M. A., Whitelaw A., Gamble J.: H-2 Gene Complex Restricts Transfer of Delayed-Type Hypersensitivity in Mice — Proc. nat. Acad. Sci. (Wash.)72, 5095, 1975.
Miller J. F. A. P., Vadas M. A., Whitelaw A., Gamble J.: Role of Major Histocompatibility Complex Gene Products in Delayed-Type Hypersensitivity — Proc. nat. Acad. Sci. (Wash.)73, 2486, 1976.
Mitchell G. F.: A Proposal that Onein Vivo Function of T Cells Is to Regulate the Availability of Antigen for B Cells — Transplant. Rev.23, 119, 1975.
Möller G., Coutinho A., Gronowicz E., Hammarström L., Smith E.: Role of Mitogenic Components of Thymus-Independent Antigens — In:Oppenheim J. J., Rosenstreich D. L. (Eds): Mitogens in Immunobiology. Academic Press, New York, 1976; p. 291.
Mosier D. E.: The Role of Macrophages in the Specific Determination of Immunogenicity and Tolerogenicity — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 35.
Nathan C. F., Hill V. M., Terry W. D.: Isolation of a Subpopulation of Adherent Peritoneal Cells with Anti-Tumour Activity — Nature (Lond.)260, 146, 1976.
Nelson D. S.: Macrophages and Immunity — North-Holland, Amsterdam, 1969.
Nelson D. S.: Macrophages as Effectors of Cell-Mediated Immunity — CRC Crit. Rev. Microbiol.1, 353, 1972.
Nelson D. S.: Nonspecific Immunoregulation by Macrophages and Their Products — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 235.
Nelson D. S.: Inhibition of Lymphocyte Transformation by Products of Macrophages and Other Cells — In:Oppenheim J. J., Rosenstreich D. L. (Eds): Mitogens in Immunobiology. Academic Press, New York, 1976; p. 477.
Nelson D. S., Hopper K. E., Nelson M.: Role of the Macrophage in Resistance to Cancer — In:Waters H. (Ed.): The Handbook of Cancer and Immunology. Garland, New York, 1977. (In Press).
Nelson D. S., Nelson M., Hopper K. E., Blanden R. V., Gardner I. D., Bowern N., Kearney R.: Possible Basis of the Immunological Success of Some Tumours — (In Preparation).
North R. J.: Importance of Thymus-Derived Lymphocytes in Cell-Mediated Immunity to Infection — Cell. Immunol.7, 166, 1973.
Nossal G. J. V., Schrader J. W.: B Lymphocyte-Antigen Interactions in the Initiation of Tolerance or Immunity — Transplant. Rev.23, 138, 1975.
Oliver J. M., Berlin R. D.: Macrophage Membranes — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 259.
Oppenheim J. J., Seeger R. C.: The Role of Macrophages in the Induction of Cell-Mediated Immunityin Vivo — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 111.
Pearsall N. W., Weiser R. S.: The Macrophage — Lea and Febiger, Philadelphia, 1970.
Pierce C. W., Kapp J. A.: The Role of Macrophages in Antibody Responsesin Vitro — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 1.
Rosenstreich D. L.: The Macrophage Requirement for Mitogenic Activation of T-Lymphocytes — In:Oppenheim J. J., Rosenstreich D. L. (Eds.): Mitogens in Immunobiology. Academic Press, New York, 1976; p. 385.
Rosenthal A. S., Blake J. T., Ellner J. J., Greineder D. K., Lipsky P. E.: Macrophage Function in Antigen Recognition by T Lymphocytes — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 131.
Schimpl A., Wecker E.: A Third Signal in B Cell Activation Given by TRF — Transplant. Rev.23, 176, 1976.
Schorlemmer H. J., Allison A. C.: Effects of Activated Complement Components on Enzyme Secretion by Macrophages — Immunology31, 781, 1976.
Seeger R. C., Oppenheim J. J.: Macrophage-Bound Antigens. II. Comparison of the Immunogenicity of Antigens Bound to Macrophages, Lymphocytes, Thymocytes and Hepatoma Cells — J. Immunol.109, 255, 1972.
Stuart A. E.: The Reticulo-Endothelial System — Livingston, Edinburgh, 1970.
van Furth R. (Ed.): Mononuclear Phagocytes — Blackwell, Oxford, 1970.
van Furth R., Cohn Z. A., Hirsch J. G., Humphrey J. H., Spector W. G., Langevoort H. L.: The Mononuclear Phagocytic System: A New Classification of Macrophages, Monocytes, and Their Precursor Cells — Bull. Wld. Hlth Org.46, 845, 1972.
Wagner H., Feldmann M., Boyle W., Schrader J. W.: Cell-Mediated Immune Responsein Vitro. III. The Requirement for Macrophages in Cytotoxic Reactions against Cell-Bound and Subcellular Alloantigens — J. exp. Med.136, 331, 1972.
Walker W. S.: Functional Heterogeneity of Macrophages — In:Nelson D. S. (Ed.): Immunobiology of the Macrophage. Academic Press, New York, 1976; p. 91.
Author information
Authors and Affiliations
Additional information
The work of the author’s laboratory is supported by grants from the National Health and Medical Research Council, the New South Wales State Cancer Council and the Australian Kidney Foundation. It is carried out in part pursuant to Research Contract N01-CB-63973 with the United States National Cancer Institute.
Rights and permissions
About this article
Cite this article
Nelson, D.S. Macrophages in immunobiology. La Ricerca Clin. Lab. 7, 93–101 (1977). https://doi.org/10.1007/BF02879475
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02879475