Skip to main content
Log in

Paternal inheritance of mitochondrial DNA in the sheep (Ovine aries)

  • Published:
Science in China Series C: Life Sciences Aims and scope Submit manuscript

Abstract

Paternal inheritance of mitochondria DNA in sheep was discovered by examination of 152 sheep from 38 hybrid families for mtDNA D-loop polymorphisms using PCR-RFLP, amplification of repeated sequence somain, and PCR-SSCP of the D-loop 5′ end region of a 253 bp fragment. Our findings have provided the first evidence of paternal inheritance of mtDNA in sheep and possible mechanisms of paternal inheritance were discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Albuquerque, L. G., Keown, J. F., Van Vleck, L. D., Variances of direct genetic effects, maternal genetic effects, and cytoplasmic inheritance effects for milk yield, fat yield, and fat percentage, J. Dairy Sci., 1998, 81(2): 544–549.

    Article  PubMed  CAS  Google Scholar 

  2. Wallace, D. C., Mitochondrial diseases in man and mouse, Science, 1999, 283: 1482–1488.

    Article  PubMed  CAS  Google Scholar 

  3. Gray, M. W., Burger, G., Lang, B. F., Mitochondrial evolution, Science, 1999, 283: 1476–1481.

    Article  PubMed  CAS  Google Scholar 

  4. Sutovsky, P., Schatten, G., Paternal contributions to the mammalian zygote: fertilization after sperm-egg fusion. Int. Rev. Cytol., 2000, 195: 1–65.

    Article  PubMed  CAS  Google Scholar 

  5. Hutchison, C. A., Newbold, J. E., Potter, S. S. et al., Maternal inheritance of mammalian mitochondrial DNA, Nature, 1974, 251: 536–538.

    Article  PubMed  CAS  Google Scholar 

  6. Kondo, R., Matsuura, E. T., Chigusa, S. I., Further observation of paternal transmission of Drosophila mitochondrial DNA by PCR selective amplification method, Genet. Res., 1992, 59(2):81–84.

    Article  PubMed  CAS  Google Scholar 

  7. Danan, C., Sternberg, D., Van Steirteghem, A., et al., Evaluation of parental mitochondrial inheritance in neonates born after intracytoplasmic sperm injection, Am. J. Hum. Genet., 1999, 65(2): 463–473.

    Article  PubMed  CAS  Google Scholar 

  8. Gyllensten, U., Wharton, D., Josefsson, A. et al., Paternal inheritance of mitochondrial DNA in mice, Nature, 1991, 352(6332): 255–257.

    Article  PubMed  CAS  Google Scholar 

  9. Shitara, H., Hayashi, J. I., Takahama, S. et al., Maternal inheritance of mouse mtDNAin interspecific hybrids: segregation of the leaked paternal mtDNA followed by the prevention of subsequent paternal leakage, Genetics, 1998, 148(2): 851–857.

    PubMed  CAS  Google Scholar 

  10. Steinborn, R., Zakhartchenko, V., Jelyazkkov, J. et al., Composition of parental mitochondrial DNA in cloned bovine embryos, FEBS Lett., 1998, 426(3): 352–356.

    Article  PubMed  CAS  Google Scholar 

  11. Lansman, R. A., Avise, J. C., Huettel, M. D. et al., Critical experimental test of the possibility of “paternal leakage” of mitochondrial DNA, Proc. Natl. Acad. Sci. USA, 1983, 80(7): 1969–1971.

    Article  PubMed  CAS  Google Scholar 

  12. Meusel, M. S., Moritz, R. F., Transfer of paternal mitochondrial DNA during fertilization of honeybee (Apis mellifera L.) eggs, Curr. Genet., 1993, 24(6): 539–543.

    Article  PubMed  CAS  Google Scholar 

  13. Sutherland, B., Stewart, D., Kenchington, E. R. et al., The fate of paternal mitochondrial DNA in developing female mussels,Mytilus edulis: implications for the mechanism of doubly uniparental inheritance of mitochondrial DNA, Genetics, 1998, 148(1): 341–347.

    PubMed  CAS  Google Scholar 

  14. Hiendleder, S., Lewalski, H., Wassmuth, R. et al., The complete mitochondrial DNA sequence of the domestic sheep (Ovis aries) and comparison with the other major ovine haplotype, J. Mol. Evol., 1998, 47(4): 441–448.

    Article  PubMed  CAS  Google Scholar 

  15. Zardoya, R., Villalta, M., Lopez-Perez, M.J. et al., Nucleotide sequence of the sheep mitochondrial DNA D-loop and its flanking tRNA genes, Curr. Genet, 1995, 28(1): 94–96.

    Article  PubMed  CAS  Google Scholar 

  16. Caetano-Anolles, G., Gresshoff, P. M., Staining nucleic acids with silver, Promega Notes, 1994, 45, 15–18.

    Google Scholar 

  17. Cummins, J. M., Wakayama, T., Yanagimachi, R. et al., Fate of microinjected spermatid mitochondria in the mouse oocyte and embryo, Zygote, 1998, 6(3): 213–222.

    Article  PubMed  CAS  Google Scholar 

  18. Lopez, J. V., Yuhki, N., Masuda, R. et al., Numt, a recent transfer and tandem amplification of mitochondrial DNA to the nuclear genome of the domestic cat, J. Mol. Evol., 1994, 39: 174–190.

    PubMed  CAS  Google Scholar 

  19. Wallace, D. C., Stugard, C., Murdock, D. et al., Ancient mtDNA sequences in the human nuclear genome: A potential source of errors in identifying pathogenic mutations, Proc. Natl. Acad. Sci. USA, 1997, 94: 14900–14905.

    Article  PubMed  CAS  Google Scholar 

  20. Eyre-Walker, A., Smith, N. H., Smith, J. M., How clonal are human mitochondria? Proc. R. Soc. Lond. B. Biol. Sci., 1999, 266(1418): 477–483.

    Article  CAS  Google Scholar 

  21. Hagelberg, E., Goldman, N., Lin, P. et al., Evidence for mitochondrial DNA recombination in a human population of island Melanesia, Proc. R. Soc. Lond. B. Biol. Sci., 1999, 266(1418): 485–492.

    Article  CAS  Google Scholar 

  22. Awadalla, P., Eyre-Walker, A., Smith, J. M., Linkage disequilibrium and recombination in Hominid mitochondrial DNA, Science, 1999, 286(5449): 2524–2525.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Xingbo Zhao.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhao, X., Chu, M., Li, N. et al. Paternal inheritance of mitochondrial DNA in the sheep (Ovine aries). Sci. China Ser. C.-Life Sci. 44, 321–326 (2001). https://doi.org/10.1007/BF02879339

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02879339

Keywords

Navigation