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Horse erythrocyte factor enhancing sulphonamide activity

I. Partial purification and data on the mode of action

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Abstract

The active principle of horse red blood cell haemolysate enhancing sulphonamide activityin vitro (HC factor) was partially purified by adsorption to DEAE-cellulose and subsequent fractionated elution. The properties of the factor, as disclosed so far, suggest that it may be a protein-containing substance of a rather high molecular weight. The HC factor counteracts the sulphonamide-antagonizing property of meat-extract, but not of peptone, of enzymic casein hydrolysate and of some known sulphonamide antagonists.

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Author notes

  1. T. Machay

    Present address: IInd Pediatric Clinic, Semmelweis Med. Univ., Budapest

Authors and Affiliations

  1. Department of Pharmacology, Semmelweis Medical University, Budapest

    E. T. Gláz & T. Machay

Authors
  1. E. T. Gláz
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  2. T. Machay
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Additional information

Part of this work was presented at the Vth Int. Congress of Chemotherapy, Vienna, 1967, by the first author.

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Gláz, E.T., Machay, T. Horse erythrocyte factor enhancing sulphonamide activity. Folia Microbiol 17, 88–94 (1972). https://doi.org/10.1007/BF02877905

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  • DOI: https://doi.org/10.1007/BF02877905

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