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Acetylsalicylic acid inhibits platelet PAI-1 antigen release without affecting circulating PAI-1 antigen in plasma

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Research in Clinic and Laboratory

Summary

An important plasminogen activator-inhibitor (PAI-1) is present in plasma and concentrated in α-granules of platelets. PAI-1 is released during platelet stimulationin vitro. It is presently unknown to what extent the treatment with acetylsalicylic acid (ASA) inhibits platelet PAI-1 release and if release inhibition has an effect on plasma PAI-1 levels. We therefore investigated by a double-blind placebo-controlled crossover study the effects of oral ASA (500 mg/day for 3 days) on platelet PAI-1 release and on plasma PAI-1 levels of healthy male volunteers. The PAI-1 release from platelets stimulated by arachidonic acid and collagen was significantly reduced by ASA: from average values of 88 and 80% to 14 and 17%, respectively (p<0.01). However, plasma PAI-1 levels were not modified by this treatment. We can conclude that platelet PAI-1 release does not play a role in modulating the plasma PAI-1 levels in healthy volunteers.

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Authors and Affiliations

  1. Clinica Medica II, Università degli Studi di Padova, Via Giustiniani 2, 35100, Padova, Italia

    Alberto Cogo & Paolo Prandoni

  2. McMaster University Medical Center, Hamilton, Ontario, Canada

    Elisabeth Ling

  3. Center for Haemostasis, Thrombosis and Atherosclerosis Research, Academic Medical Center, University of Amsterdam, Italia

    Augueste Sturk & Jan Wouter ten Cate

Authors
  1. Alberto Cogo
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  2. Elisabeth Ling
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  3. Augueste Sturk
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  4. Jan Wouter ten Cate
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  5. Paolo Prandoni
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Cogo, A., Ling, E., Sturk, A. et al. Acetylsalicylic acid inhibits platelet PAI-1 antigen release without affecting circulating PAI-1 antigen in plasma. Res. Clin. Lab. 20, 113–117 (1990). https://doi.org/10.1007/BF02877557

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  • DOI: https://doi.org/10.1007/BF02877557

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