Abstract
The frequency ofhis + revertants induced by N-methyl-N-nitrosourea (MNU) and N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) in the strain TA100 ofSalmonella typhimurium was decreased by gallic and tannic acid. In weak buffer solutions, the inhibition effects of gallic acid towards MNU and MNNG mutagenicity was caused primarily by a decrease of pH in the incubation mixtures. At adjusted pH (pH 5.0 and 6.5), the antimutagenic effects are largely the result of an interaction between MNU or MNNG with phenolic acids outside the cells.
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Abbreviations
- MNU:
-
N-methyl-N-nitrosourea
- MNNG:
-
N-methyl-N′-nitro-N-nitrosoguanidine
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Gichner, T., Pospíšil, F., Velemínský, J. et al. Two types of antimutagenic effects of gallic and tannic acids towards N-nitroso-compounds-induced mutagenicity in the amesSalmonella Assay. Folia Microbiol 32, 55–62 (1987). https://doi.org/10.1007/BF02877259
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DOI: https://doi.org/10.1007/BF02877259