Abstract
Saccharomyces cerevisiae accumulates Δ5,7-sterols up to 4 mg per g biomass. The differential rate of sterol synthesis continually increases during growth, its value only being decreased at sterol levels higher than 30 mg per g biomass. The specific rate of sterol synthesis reaches a broad maximum during the growth phase. The gradual sterol accumulation pattern is dominant in cultures growing both on fermentable and nonfermentable carbon sources and is modulated by glucose repression. Limited feeding with sucrose has a significantly greater negative impact on sterol accumulation than feeding with ethanol as a carbon source.
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Novotný, Č., Běhalová, B., Doležalová, L. et al. Kinetics of Δ5,7-sterol accumulation during growth ofSaccharomyces cerevisiae . Folia Microbiol 32, 13–23 (1987). https://doi.org/10.1007/BF02877253
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DOI: https://doi.org/10.1007/BF02877253