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Microbial transformation of steroids

XX. Transformation reactions of steroids as a diagnostic feature in the classification of actinomycetes

Микробиальная трансформация стеридов

ХХ. трансформационная реакция стероидов как. один из диагностических критериев классификации актиномицетов

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Abstract

A systematic study of transformation reactions of Actinomycetes with respect to the progesterone molecule was undertaken. The results obtained, i.e. the types of transformation reactions in different actinomycete species, were evaluated from the point of view of taxonomy. The actinomycetes tested were divided according to the transformation types into three groups: (1) a group of species transforming progesterone in the 16α-position; (2) a group of species transforming progesterone in the β-position; (3) a group of species in which no capacity to transform progesterone into another steroid derivative was established.

From the point of view of Actinomycete classification the transformation reactions on the steroid molecule fulfil all the requirements of taxonomic features of Actinomycetes. They appear to be specific properties, independent of strictly cultivation conditions and common to all the strains of individual actinomycete species tested.

Abstract

На молекуле прогестерона систематически изучалась трансформационная реакция актиномицетов. Полученные нами данные относительно типов трансформационных, реакций у различных видов и штаммов актиномицеров оценивались с точки зрения критерия таксономических признаков. Исследуемые актиномицеты были разделены на З группы по типу трансформации: 1) группа видов, трансформирующих прогестерон в положении 16 α, 2) группа видов, трансформирующих прогестерон в положении 6β и 3) группа видов, у которых не была обнаружена способность к трансформации прогестерона в другой стероидный дериват.

Трансформационные реакции в молекуле стероидов отвечают требованиям, предъявляемым к таксономическим признакам актиномицетов с точки зрения классификации актиномицетов. Они являются специфическим признаком, не зависящим, в строгом смысле слова, от условий кулытивации и общим для всех исследовавшихся до сих пор штаммов отдельных видов актиномицетов.

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Authors and Affiliations

  1. Institute of Microbiology, Czechoslovak Academy of Sciences, Prague 6

    Olga Vondrová & A. Čapek

  2. Research Institute for Pharmacy and Biochemistry, Prague 3

    Olga Vondrová & A. Čapek

Authors
  1. Olga Vondrová
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  2. A. Čapek
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Vondrová, O., Čapek, A. Microbial transformation of steroids. Folia Microbiol 8, 117–119 (1963). https://doi.org/10.1007/BF02877233

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