Abstract
Addition ofL-valine andDL-isoleucine to the cultivation medium ofStreptomyces cinnamonensis was found to affect the ratio of synthesized monensins A and B. In the presence ofL-valine monensin A is synthesized predominantly, whereas in the presence ofDL-isoleucine the production of monensin B increases.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Agtarap A., Chamberlin J.W., Pinkerton M., Steinbauf L.K.: The structure of monensic acid, a new biologically active compound.J. Am. Chem. Soc. 89, 5737 (1967).
Day L.E., Chamberlin J.W., Gordee E.Z., Chen S., Gorman M., Hamill R.L., Ness T., Weeks R.E., Stroshane R.: Biosynthesis of monensin.Antimicrob. Agents Chemother. 4, 410 (1973).
Dorman D.E., Paschal J.W., Nakatsukasa W.M., Huckstep L.L., Neuss N.: The use of13C-NMR spectroscopy in biosynthetic studies. Biosynthesis of narasin, a new polyether ionophore from fermentation ofStreptomyces aureofaciens, Helv. Chim. Acta 59, 2625 (1976).
Furumai T., Takeda K., Suzuki M.: Studies on the biosynthesis of basic 16-membered macrolide antibiotivs, platenomycinsJ. Antibiotics 28, 789 (1975).
Gebsch D., Bockeb H., Thrum H.: Biosynthetic studies on the macrolide antibiotic turimycin using14C-labeled precursors.J. Antibiotics 30, 488 (1977).
Gorman M., Chamberlin J.W., Hamill R.L.: Monensin, a new biologically active compound. V. Compounds related to monensin.Antimicrob. Agents Chemother. 363 (1967).
Komatsubara S., Kisumi M., Chibata I.: Transductional construction of an isoleucine-producing strain ofSerratia marcescens.J. Gen. Microbiol. 119, 51 (1980).
Miyagawa K., Suzuki M., Higashide E., Uchida M.: Effect of aspartic acid family amino acids on production of maridomycin III.Agric. Biol. Chem. 43, 1103 (1979).
Reuter G., Hüttner R.: Valin und leucin als mögliche Vorstufen von Isobuttersäure resp. Isovaleriansäure in Turimycin.Biochem. Physiol. Pfl. 169, 1 (1976).
Tax J., Sedmera P., Vokoun J., Karnetová J., Stajner K., Krumphanzl V., Vaněk Z.: Phenazine derivatives fromStreptomyces cinnamonensis. Coll. Czechoslov. Chem. Commun., in press (1982).
Vézina C., Bolduc C., Kudelski A., Audet P.: Biosynthesis of kitasamycin (leucomycin) by leucine analog-resistant mutants ofStreptomyces kitasatoensis.Antimicrob. Agents Chemother. 15, 738 (1979).
Westley J.W.: Polyether antibiotics: Versatile carboxylic acid ionophores produced byStreptomycea.Adv. Appl. Microbiol. 22, 177 (1977).
Westley J.W.: Polyether antibiotics — biosynthesis, p. 41 inAntibiotics, Vol. IV, Biosynthesis (J.W. Corcoran, Ed.). Springer Verlag, Berlin — Heidelberg — New York 1981.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pospíšil, S., Královcová, E., Stajner, K. et al. Regulation of biosynthesis of monensins on chemically defined medium. Folia Microbiol 27, 275–277 (1982). https://doi.org/10.1007/BF02877130
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02877130