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The Knoevenagel reaction of malononitrile with acetylacetone: New route of pyrazole, pyrazolo[2,3-C]pyridine, benzene, pyridazine and benzo[C]pyridazine derivatives

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Abstract

The Knoevenagal reaction of malononitrile and acetylacetonegave the acyclic product 3 whichwas separated in a good yield and identified. The reactivity of 3 towards some chemical reagents is studied. Thus, the reaction of 3 with aromatic aldehydes, hydrazines and cyanomethylene derivativesgave products 6–12. Reaction of 3 with benzenediazonium chloridegave the primidine derivative 14.

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  1. Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt

    Rafat Milad Mohareb

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  1. Rafat Milad Mohareb
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Mohareb, R.M. The Knoevenagel reaction of malononitrile with acetylacetone: New route of pyrazole, pyrazolo[2,3-C]pyridine, benzene, pyridazine and benzo[C]pyridazine derivatives. Arch. Pharm. Res. 14, 379–384 (1991). https://doi.org/10.1007/BF02876888

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  • DOI: https://doi.org/10.1007/BF02876888

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