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Effects of cyanein and ramihyphin A on the dimorphism ofParacoccidioides brasiliensis

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Abstract

As a preliminary step in the study of dimorphism mParacoccidioides brasiliensis, the effects of cyanem and ramihyphin A were studied. These antibiotics have been reported to induce morphological changes in fungi The results obtained suggest that ramihyphin A induce swelling of hyphae while partially inhibiting Y → M transformation with the production of an incipient and swollen mycelium. Cyanem did not affect the mycelial morphology as did ramihyphin A However, the Y → M transformation was inhibited and, also, the M → Y transformation was blocked with the production of a few yeast cells which were not released from the mycelium.

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Authors and Affiliations

  1. Centro de Microbiologia y Biologia Celular, Instituto Venezolano de Investigaciones Cientificas, (IVIC), Apartado 1827, Caracas, Venezuela

    G. San-Blas & F. J. Yegres

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  1. G. San-Blas
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  2. F. J. Yegres
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San-Blas, G., Yegres, F.J. Effects of cyanein and ramihyphin A on the dimorphism ofParacoccidioides brasiliensis . Folia Microbiol 23, 198–201 (1978). https://doi.org/10.1007/BF02876579

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  • DOI: https://doi.org/10.1007/BF02876579

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