Abstract
The macrolide aglycosidic antibiotic vermiculine, added to the cultivation medium to a concentration of 30 μg/ml, has anin vitro inhibitory effect onTritrichomonas foetus. The agent interacts rapidly with the cells, causing irreversible changes after several hours of action. The changes are not repaired on removing the agent; the cells suffer from a rapid inhibition of nucleic acid synthesis, the protein synthesis remaining intact.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Boeckmann R. K., Fayos J., Clardy J.: A revised structure of vermiculine. A novel macrolide dilactone antibiotic fromPenicillium vermiculatum.J. Amer. Chem. Soc. 96, 5954 (1974).
Corey E. K., Nicolaou K.C., Toru T.: Total synthesis of vermiculine.J. Amer. Chem. Soc. 97, 2287 (1975).
Diamond L. S.: The establishment of various Trichomonads of animal and man in axenic cultures.J. Parasit. 43, 488 (1957).
Fuska J., Nemec P., Kuhr I.: Vermiculine, a new antiprptozoal antibiotic fromPenicillium vermiculatum.J. Antibiotics 25, 208 (1972).
Fuska J., Ivanitskaya L. P., Horáková K., Kuhr I.: The cytotoxic effect of a new antibiotic vermiculine.J. Antibiotics 27, 141 (1974).
Grawen S. N., Lardy H. A., Estrada O.: Antibiotics as tools for metabolic studies. VIII. Effect of nonactin homologs on alkali metal cation transport and rate of respiration in mitochondria.Biochemistry 6, 365 (1963).
Horáková K., Kernáčová B., Nemec P., Fuska J.: Characterization of the cytotoxic activity of vermiculine.J. Antibiotics 29, 1109 (1976).
Kinsky S. C.: Comparative responses of mammalian erythrocytes and microbial protoplasts to polyene antibiotics and vitamin A.Arch. Biochem. Biophys. 102, 180 (1963).
Korner B., Jensen H. K.: Sensitivity ofTrichomonaa vaginalis to metronidazole, tinidazole, and nifuratelin vitro. Brit. J. Vener. Dis.52, 404 (1976).
Kováč L., Bōhmerová E., Fuska J.: Inhibition of mitochondrial functions by antibiotics bikaverin and duclauxin.J. Antibiotics 30, 616 (1977).
Paredes F. R., Hawkins D. F.: Sensitivity ofTrichomonaa vaginalia to chemotherapeutic agents.J. Obat. Gynaecol. Brit. Comm. 80, 86 (1973).
Seebach D., Seuring B., Kalinowski H. O., Lubosch W., Renger B.: Synthese und Bestimmung der absoluten Konfiguration der makrozyclischen Dilactone Pyrenophorin und Vermiculin.Angew. Chemie 89, 270 (1977).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fusková, A., Fuska, J. & Kettner, M. Inhibition ofTritrichomonas foetus by vermiculinein vitro . Folia Microbiol 23, 389–393 (1978). https://doi.org/10.1007/BF02876441
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02876441