Summary
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1.
122 hypercholesterolemic patients followed ahigh-fat diet. 91 of them took a teaspoon of soy bean phospholipids with each meal. The remaining 31 served as controls.
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2.
The blood cholesterol came down in 79% of the patients who took phospholipids. In the controls there was no tendency for the cholesterol to either rise or fall.
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3.
This indicates that it may he possible to correct hypercholesterolemia while the patient eats a highfat, high-cholesterol diet.
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4.
Evidence is reviewed which suggests that the fat may aid in correcting this lipid dyscrasia.
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5.
This therapy tends to reduce hypercholesterolemia by promoting healthy lipid metabolism.
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Bibliography
Adlersberg, D., and Sobotka, H. J.: Effect of prolonged lecithin feeding ou hypercholesterolemia.J. Mt. Sinai Hosp., 9: 995, 1943.
Ahmed, B.:Biochem. J., 25: 1195, 1931.
Barker, N. W.:Ann. Int. Med., 13: 685, 1939.
Basil, N. K.:Ztschr. Vitaminforsch., 6:.106, 1937.
Best, C. H., W. S. Hartroft, and C. C. Lucas.Brit. Med. J., 2: 1001, 1949.
Best, C. H.: Diabetes and Insulin and The Lipotropic Factors. Charles C. Thomas, Springfield, Illinois, 1948.
Bloch, K., and E. Borek and D. Rittenberg,J. Biol. Chem., 162: 441, 1946.
Boas, E. P., and D. Adlersberg: Familial hypercholesterolemia and atherosclerosis,J. Mt. Sinai Hosp., 12:84, 1945.
Byers, S. O., M. Friedman, and F. Michaels: Plasma Cholesterol after bile duct ligation and free cholesterol injection,J. Biol. Chem., 184: 71, 1950.
Chanutin, A., and S. Ludwig:J. Biol. Chem., 115: 1, 1936.
Chernick, S., P. A. Srere, and Chaikoff, I. L.: The formation in vitro of fatty acids and phospholipids by rat artery with C-14 and P-32 as indicators.J. Biol. Chem., 179:113, 1949.
Chiodi, H. and A. F. Cardeza:Arch. Path., 48:395, 1949.
Dam, H., and E. M. Kelman: The effect of vitamin E on the blood plasma lipids of the chick.Science, 96: 430, 1942.
Davis, D., and Stern, B. and Lesnick, G.:Ann. Int. Med., 11:354, 1937.
Dragstedt, L. R., D. E. Clark, O. C. Julian, C. Vermuelen, and W. C. Goodpasture:Surg., 8: 353, 1940.
Duff, G. L.:Arch. Path., 20: 81, 1935. 20:259, 1935. 22: 161, 1936.
Engel, R. W.: The relation of B-vitamins and dietary fat to the lipotropic action of choline,J. Nutr., 24:175, 1942.
Entenman, C., G. W. Changus, G. E. Gibbs, and I. L. Chaikoff: The effects of fasting and chronic undernutrition upon the post absorptive level of the blood lipids.J. Biol. Chem., 134: 59, 1940.
Epstein, E. Z..Arch. Int. Med., 50:203, 1932.
Epstein, E. Z., and E. B. Greenspan:Arch. Int. Med., 58:860, 1936.
Felch, W. C. : Cholesterol metabolism in health and disease.N. Y. Med., October 5, 1949.
Folch, J. and D. W. Woolley,J. Biol. Chem., 142:963, 1942.
Forbes, J. C.: Vitamin B complex and fat metabolism,J. Nutr., 22: 359, 1941.
Gavin, G., and McHenry, E. W.: Inositol: a lipotropic factor,J. Biol. Chem., 139: 485, 1941.
Gavin, G., and McHenry, E. W.: The effects of biotin upon fat synthesis and metabolism,J. Biol. Chem., 141: 619, 1941.
Gertler, M. M., S. M. Garn, and P. D. White: Diet, serum cholesterol, and coronary artery disease,Circul., 2: 696, 1950.
Gibbs, C. B. F., E. Ruckner, and W. R. Bloor,New Eng. J. Med., 209: 384, 1933.
Gofman, J. W., H. B. Jones, F. T. Lindgren. et al. Blood lipids and human atherosclerosis,Circul., 2: 161, 1950.
Gross, P. and B. Kesten: The treatment of psoriasis with lipotropic substances derived from foodstuffs,Arch. Derm, and Syph., 47: 159, 1943.
Grutz, O., and M. Burger: Die Psoriasis als Stoffwechselproblem,Klin. Wchnschr., 12:373, 1933.
Grutz. O., Neue histologische Beiträge zum Psoriasisproblem,Arch. f. Dermat. u. Syph., 177:246, 1938.
Hawkins, W. B. and A. Wright:J. Exp. Med., 59:427, 1934.
Heinrich, M. R. and H. A. Matill: Lipids of muscle and brain in rats deprived of tocopherol.Proc. Soc. Exp. Biol. Msd., 52: 344, 1943.
Henlein, H.:Z. ges. exp. Med., 91:638, 1933.
Hershey, J. M.Am. J. Physiol., 93: 657, 1930.
Hershey, J. M. and S. Soskin:Am. J. Physiol., 98:74, 1931.
Hickman, K. C. D., and P. L. Harris:Advances in Enzymology, 6: 469, 1946.
Hickman, K. C. D., and P. L. Harris:Advances in Enzymology, 6: 469, 1946.
Jaffe, E. R., Humphreys, E. M., E. P. Benditt, and R. W. Wissler,Arch. Path., 47: 411, 1949.
Kempner, W., Treatment of hypertensive vascular disease with rice diet.Am. J. Med., 4: 545, 1948.
Kesten, H. D., and Silbowitz, R.: Experimental atherosclerosis and soya lecithin.Proc. Soc. Exper. Biol. Med., 49:71, 1942.
Keys, A., O. Mickelsen, E. V. O. Miller and C. B. Chapman: The relation in man between cholesterol levels in the diet and in the blood,Science, 112:79, 1950.
Madden, J. F.:Arch. Derm, and Syph., 44:655, 1941.
Man, E. B., B. L. Kartin, S. H. Durlacher, J. P. Peters,J. Clin. Invest., 24: 623, 1945.
Marx, W., L. Marx, E. R. Meserve, F. Shimoda, and H. J. Deuel,: The effects of the administration of a vitamin E concentrate and of cholesterol and bile salt on the aorta of the rat,Arch. Path., 47: 440, 1949.
Mason, K. E. and J. L. Filer,: Interrelationships of dietary fat and tocopherols,J. Am. Oil Chem. Soc, 24: 240, 1947.
Meeker, D. R. and H. D. Kesten:Arch. Path., 31:147, 1941.
Mjassnikow, A. L.:Ztschr. f. Min. Med., 102:65, 1925.
Montgomery, H., and A. E. Osterberg:Arch. Derm. and Syph., 37: 373, 1938.
Morgulis, S., V. M. Wilder, H. C. Spencer, and S. H. Eppstein,J. Biol. Chem., 124: 755, 1938.
Morrison, L. M.: Arteriosclerosis:J. A. M. A., 145:1232, 1951.
Muller, C.:Arch. Int. Med., 64: 675, 1939.
Poindexter, C. A., and M. Bruger:Arch. Int. Med., 61:714, 1938.
Quaife, M. L. and Y. D. Mei Chemical estimation of vitamin E in tissues and tocopherol content of some normal human tissues.J. Biol. Chem., 180:263, 1949.
Rabinowitsch, I. M.:Ann. Int. Med., 8:1436, 1935.
Rittenberg, D. and K. Bloch,J. Biol. Chem., 160:417, 1945.
Rogers, C. S., C. C. Ferguson, C. E. Friedgood, and H. M. Vars: Influence of fat in the diet upon nitrogen balance and liver regeneration.Am. J. Physiol., 163: 347, 1950.
Sachs, H. W.. Vitamin A and fatty change in the liver,Virchow’s Arch. path. anat. u. Physiol., 309:712, 1942.
Scholfield, C. R., H. J. Dutton, F. W. Tanner, and J. C. Cowan:J. Am. Oil Chem. Soc, 25:368, 1948.
Srere, P. A., I. L. Chaikoff, S. S. Treitman, L. S. Burstein: The extra-hepatic synthesis of cholesterol.J. Biol. Chem., 182: 629, 1950.
Thannhauser, S. J., and H. Magendantz: Different clinical groups of xanthomatous diseases; clinical physiological study of 22 cases.Ann. Int. Med., 11:1662, 1938.
Treadwell, C. R., and H. C. Eckstein: The effect of high and low fat diets on the cholesterol metabolism of four generations of white rats.J. Biol. Chem., 140:35, 1941.
Turner, K. B. and A. Steiner: A long term study of the variation of the serum cholesterol in man.J. Clin. Invest., 18: 45, 1939.
Wilkinson, C. F., E. Blecha, and A. Reimer: Is there a relation between diet and blood cholesterol?Arch. Int. Med., 85:389, 1950.
Wilson, H. E. C., Das Gusta, S. M., and B. Ahmed.,Indian J. Med. Res., 24: 807, 1937.
White, P.:Bulletin N. Y. Acad. Med., 10:347, 1934.
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Pottenger, F.M., Krohn, B. Reduction of hypercholesterolemia byhigh-fat diet plus soybean phospholipids. Amer. Jour. Dig. Dis. 19, 107–109 (1952). https://doi.org/10.1007/BF02876315
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DOI: https://doi.org/10.1007/BF02876315