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Steroid derivatives XXX

Transformation of steroids by microorganisms of the genusFlavobacterium

Дериваты стероидов XXX

Трансформация стероидов микроорганизмами рода Flavobacterium

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Abstract

The ability of microorganisms of the genusFlavobacterium to transform derivatives of the pregnane series was tested. The ability of all five test strains to hydrolyse ester groups present in the steroid molecule was weak or negligible. Three strains showed very strong ability to dehydrogenate the Δ5-3β-ol to Δ4-3-ketone grouping without splitting off the side chains or the 21-acetoxy-group (if present).

Abstract

Микроорганизмы рода Flavobacterium тестировались на способность трансформировать дериваты ряда прегнана. У пяти тестировавшихся штаммов во всех случаях была установлена очень слабая или ничтожная способность гидролизировать группы эфиров, присутствующие в молекуле стероида. У трех штаммов была замечена очень сильная способность дегидрогенировать Δ5-3β-ол на Δ4-3-кетон без отщепления боковых цепей или же могущую присутствовать 21-ацетоксигруппу.

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Authors and Affiliations

  1. Research Institute for Natural Drugs, Prague 9

    J. Protiva, V. Schwarz & K. Syhora

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  1. J. Protiva
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  2. V. Schwarz
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  3. K. Syhora
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Protiva, J., Schwarz, V. & Syhora, K. Steroid derivatives XXX. Folia Microbiol 9, 218–221 (1964). https://doi.org/10.1007/BF02875840

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  • DOI: https://doi.org/10.1007/BF02875840

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