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[trans-en2Os (ŋ-H2)]2 + as an1H NMR probe for the coordination of some anticancer metal complexes to deoxyguanotide

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Abstract

The molecular hydrogen complex of osmium, [trans-en2Os (ŋ-H2)]2+ (en, entlylendediamine) is a new1H NMR recognition probe for biomolecules. By using this probe, the coordination between deoxyguanylic acid (dGMP) and four metal anticancer complexes, titanocene dichloride, (C2H5)2SnCl2(phen). (C2H5)2SnCl2 and cisplatin are studied in D2O under the condition near the physiological one. The results show that the former three complexes mainly and strongly coordinate with the phosphate oxygen of dGMP, while cisplatin mainly coordinates with N(7) of dGMP.

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Authors and Affiliations

  1. Institute of Molecular Science, Shanxi University, 030006, Taiyuan, China

    Pin Yang & Maolin Guo

  2. State Key Laboratory of Coordination Chemistry, Nanjing University, 210093, Nanjing, China

    Qingshan Li & Yanni Tian

  3. Department of Chemistry, Stanford University, 94305, Stanford, CA, USA

    Zai-Wei Li & Henry Taube

Authors
  1. Pin Yang
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  2. Maolin Guo
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  3. Qingshan Li
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  4. Yanni Tian
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  5. Zai-Wei Li
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  6. Henry Taube
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Project supported by the National Natural Science Foundation of China, the Natural Science Foundation of Shanxi Province and the Youth Science Foundation of Shanxi Province.

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Yang, P., Guo, M., Li, Q. et al. [trans-en2Os (ŋ-H2)]2 + as an1H NMR probe for the coordination of some anticancer metal complexes to deoxyguanotide. Sc. China Ser. B-Chem. 40, 541–547 (1997). https://doi.org/10.1007/BF02875425

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  • DOI: https://doi.org/10.1007/BF02875425

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