Skip to main content
SpringerLink
Log in

Relationships between antithrombogenicity and surface free energy of regenerated silk fibroin films

  • Published:
Fibers and Polymers Aims and scope Submit manuscript

Abstract

Silk fibroin (SF) was dissolved in calcium chloride/ethanol/water mixture (1/2/8 in mole ratio) at 70°C for 4 h. The dissolved silk fibroin was regenerated by casting the dialyzed solution into the films. The films were treated with 50% aqueous solution of methanol for different times, and their antithrombogenicity was evaluated byin vitro andin vivo tests.In vivo blood tests were made by a method of peripheral vein indwelling suture. It was found that the silk fibroin had a good anti-thrombogenicity and an absorbability even though the polymer showed foreign body reaction. Finally, the blood compatibilty of silk fibroin films which were subjected to structural change by the methanol treatment, was examined in connection with their interfacial surface energy, and a correlation between these properties was found to be present.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. C. J. van Delden, G. H. M. Engbers, and J. Feijen,J. Biomater. Sci., Polymer Ed.,7, 727 (1996).

    Article  Google Scholar 

  2. K. Kataoka, T. Tsuruta, T. Akaike, and Y. Sakuri,Makromol. Chem.,181, 1263 (1980).

    Article  Google Scholar 

  3. J. H. Elam and H. Nygren,Biomaterials,13, 3 (1992).

    Article  CAS  Google Scholar 

  4. D. Byrom, “Biomaterials-Novel Materials from Biological Sources”, Stockton Press, New York, 1991.

    Google Scholar 

  5. K. Hirabayashi,Sen-i Gakkaishi,40, 119 (1984).

    Google Scholar 

  6. H. Sakabe, H. Ito, T. Miyamoto, Y. Noishiki, and W. S. Ha,Sen-i Gakkaishi,45, 487 (1989).

    CAS  Google Scholar 

  7. Y. Noishiki, H. Ito, T. Miyamoto, and H. Inagaki,Kobunshi Ronbunshu,39, 221 (1982).

    CAS  Google Scholar 

  8. H. Ito, T. Miyamoto, H. Inagaki, and Y. Noishiki,Kobunshi Ronbunshu,39, 249 (1982).

    CAS  Google Scholar 

  9. T. Asakura, M. Demura, and M. Tsutsumi,Makromol. Chem., Rapid Commun.,9, 835 (1988).

    Article  CAS  Google Scholar 

  10. H. Yoshimizu and T. Asakura,J. Appl. Polym. Sci.,40, 127 (1990).

    Article  CAS  Google Scholar 

  11. M. Demura, T. Takekawa, T. Asakura, and A. Nishikawa,Biomaterials,13, 276 (1992).

    Article  CAS  Google Scholar 

  12. N. V. Bhat and S. M. Ahirras,J. Polym. Sci., Polym. Chem.,21, 1273 (1983).

    CAS  Google Scholar 

  13. A. W. Neumann, M. A. Moscarello, W. Zingg, O. S. Hum, and S. K. Chang,J. Polym. Sci. Symp.,66, 391 (1979).

    Article  CAS  Google Scholar 

  14. H. Ito, T. Miyamoto, H. Inagaki, Y. Noishiki, H. Iwata, and T. Matsuda,J. Appl. Polym. Sci.,32, 3413 (1986).

    Article  CAS  Google Scholar 

  15. W. S. Ha, S. K. Oh, J. H. Kim, and K. Y. Kim,Sen-i Gakkaishi,43, 587 (1987).

    CAS  Google Scholar 

  16. D. H. Kaeble and J. Moacanin,Polymer,18, 475 (1977).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Textile Engineering, Chungnam National University, 305-764, Taejon, Korea

    Won Ho Park, Wan Shik Ha, Hiraku Ito, Takeaki Miyamoto, Hiroshi Inagaki & Yasuharu Noishiki

  2. Department of Fiber and Polymer Science, Seoul National University, 151-742, Seoul, Korea

    Wan Shik Ha

  3. Saint Agnes’ Junior College, Nanpeidai, Takatuki, Osaka, Japan

    Hiraku Ito

  4. Institute for Chemical Research, Kyoto University, 611, Uji, Kyoto, Japan

    Takeaki Miyamoto & Hiroshi Inagaki

  5. First Department of Surgery, School of Medicine, Yokohama City University, 236, Yokohama, Japan

    Yasuharu Noishiki

Authors
  1. Won Ho Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wan Shik Ha
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hiraku Ito
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Takeaki Miyamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hiroshi Inagaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yasuharu Noishiki
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Won Ho Park.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Park, W.H., Ha, W.S., Ito, H. et al. Relationships between antithrombogenicity and surface free energy of regenerated silk fibroin films. Fibers Polym 2, 58–63 (2001). https://doi.org/10.1007/BF02875259

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02875259

Keywords

Search

Navigation