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Superiority of CA 125 over CA 19-9 and CEA for epithelial ovarian malignancies

  • Cancer
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Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

In this study tumor markers CA 125, CEA and CA 19-9 were evaluated to assess the best tumor marker for epithelial ovarian carcinomas in diagnosis, prognosis and management. The results indicated that CA 125 is the best and the most superior marker today for the epithelial ovarian malignancies irrespective of the histologic type. CA 125 has the highest positivity rate in mucinous tumors compared to CEA and CA 19-9. Combined assay of either CEA or CA 19-9 or both along with CA 125 did not increase diagnostic sensitivity compared to sensitivity achieved by CA 125 alone for epithelial tumors of the ovary. Serum CA 125 concentration correlated well with pretherapy, stable course and recurrence of ovarian carcinoma. CA 125 could be used effectively for diagnosis, prognosis and monitoring of the ovarian malignancies as evident from long term follow up of adenocarcinoma ovary.

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Authors and Affiliations

  1. Department of Biochemistry, Nizam's Institute of Medical Sciences, Punjagutta, 500 482, Hyderabad

    A. Saraswathi & T. Malati (Head)

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  1. A. Saraswathi
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  2. T. Malati
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Saraswathi, A., Malati, T. Superiority of CA 125 over CA 19-9 and CEA for epithelial ovarian malignancies. Indian J Clin Biochem 10, 23–28 (1995). https://doi.org/10.1007/BF02873664

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  • DOI: https://doi.org/10.1007/BF02873664

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