Skip to main content
SpringerLink
Log in

Strain variation and gene hunting in malaria

  • Malaria
  • Published:
Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

Malaria still remains uncontrolled affecting millions and killing many. We have found the high chloroquine-resistance in Rajasthan epidemic which contains multipleP.falciparum strains. Large number of variantP.falciparum strains exist in India which should be taken into account for future malaria control strategies. We have characterised several parasite molecules which are involved in the hostparasite interaction. They can be used to develop the molecular therapy or antimalarial drugs for malaria. The parasite enzymes described by us will be quite useful in this regard, particularly in drug development.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kilejian, A., Sharma, Y.D., Karoui, H. and Naslund, L. (1986) Histidine-rich domain of the knob protein of human malaria parasitePlasmodium falciparum. Proc. Natl. Acad. Sci. USA, 83, 7839–7841.

    Article  Google Scholar 

  2. Sharma, Y.D. and Kilejian, A., (1987) Primary structure of knob protein (KP) gene ofPlasmodium falciparum. Mol. Biochem. Parasitol, 26, 11–26.

    Article  PubMed  CAS  Google Scholar 

  3. Kant, R. and Sharma, Y.D. (1997) Allelic forms of the knob-associated histidine-rich protein gane ofPlasmodium falciparum. FEBS letters, 380, 147–151.

    Article  Google Scholar 

  4. Joshi, B., Biswas, S. and Sharma, Y.D. (1992) Effect of heat-shock onPlasmodium falciparum viabilibity, growth and expression of the heat-shock protein ‘PFHSP70-l’ gene. FEBS Letters 312, 91–94.

    Article  PubMed  CAS  Google Scholar 

  5. Sharma, Y.D., Sharma, V.P., Ray, P., Laal, S., Sawant, S. and Verma, S. (1991) Isolation and serological characterization of aPlasmodium vivax recombinant antigen. Infect. Immun, 59, 1922–1926.

    PubMed  CAS  Google Scholar 

  6. Ray, P. and Sharma, Y.D. (1992) Molecular cloning and serological characterization of a newPlasmodium vivax recombinant antigen which contains apolipoprotein B-100 like sequences. Biochem. Biophys. Res. Commn. 184, 668–672.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biotechnology, All India Institute of Medical Sciences, 110029, New Delhi, India

    Y. D. Sharma, J. M. Fakruddin, Nidhi Bhutani, Reena Kaushik, O. K. Raina & Indu Sharma

Authors
  1. Y. D. Sharma
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. M. Fakruddin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nidhi Bhutani
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Reena Kaushik
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. O. K. Raina
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Indu Sharma
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sharma, Y.D., Fakruddin, J.M., Bhutani, N. et al. Strain variation and gene hunting in malaria. Indian J Clin Biochem 12 (Suppl 1), 49–51 (1997). https://doi.org/10.1007/BF02873057

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02873057

Key Words

Search

Navigation