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Dietary restriction (DR) and its advantages

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Abstract

Dietary restriction (DR) also called dietary control or calorie restriction is reported to have many advantages with regard to human health. It leads to suppression of obesity, mitigates free radicals and increases available antioxidants which are accounted for extending the life span of individuals. DR is also reported to induce synthesis of heat shock proteins in animals as a control mechanism against stress. Further, it is known to play a significant role in decreasing toxicity and lethality due to a variety of toxic chemicals and drugs by stimulating tissue repair damaged by the toxicants leading to restoration of intact organ and its functions. Moreover, extensive work done on animals indicate DR has an important role in suppressing certain types of cancer. In this review an effort is made to highlight the various advantages of DR from the point of human health perspective.

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References

  1. Masaro, E.E. (1988) Food restriction in rodents: An evaluation of its role in the study of aging. J. Gerontol. 43, 59–64.

    Google Scholar 

  2. Kari, F.W., Dunn, S.E., French, J.E. and Barrett, J.C. (1999) Roles for insulin-like growth factor-1 in mediating the anti-carcinogenic effects of caloric restriction. J. Nutr. Health Aging 3, 92–101.

    PubMed  CAS  Google Scholar 

  3. Skillman, T.G. and Tzagournis, M. (1978) Diabetes mellitus. College of Medicine, Ohio State Uni. Upjohn publishers.

  4. Flier, J.S. (2001) Obesity in Harrison’s principles of internal medicine, Eds Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L. and Jameson, J.L. 15th Ed, Vol. 1 Mc Graw-Hill N. York pp 479–490.

    Google Scholar 

  5. Lissner, L. and Heitmann, B.L. (1995) Dietary fat and obesity. Evidence from Epidemiology. Eur. J. Clin. Nutr. 49, 79–85.

    PubMed  CAS  Google Scholar 

  6. Vasudevan, D.M. and Shreekumari, S. (2001) Textbook of Biochemistry. 3rd Ed. Jaypee Brothers Medical publishers Ltd., New Delhi, pp 95–102.

    Google Scholar 

  7. Kovach, M.K., Hermann, M. and Winick, M. (1999). The psychological ramnification of weight management. J. Women’s Health, Gender Based Medicine. 8, 477–482.

    Google Scholar 

  8. Zachwieja, J.J. (1996) Exercise as treatment for obesity. Endocrinol. Metab. Clin. North Am. 25, 965–988.

    Article  PubMed  CAS  Google Scholar 

  9. Kennedy, E.T., Bowman, S.A., Spence, J.T., Freedman, M. and King, J. (2001) Popular diets: correlation to health, nutrition and obesity. J. Am. Diet. Assoc. 101, 411–420.

    Article  PubMed  CAS  Google Scholar 

  10. Cowburn, G., Hillsdon, M. and Hankey, C.R. (1997) Obesity management by life style strategies. Br. Med. Bull. 53, 389–408.

    PubMed  CAS  Google Scholar 

  11. Narasimhaswamy, K.N., Ramaswamy, C., Rao, S.B. and Vasudev, R. (1995) Anorexigenic effect of fecal extract from ventro medial hypothalamic lesioned rats on normal rats. Indian J. Expt. Biol. 33, 101–104.

    CAS  Google Scholar 

  12. Barzilai, N. and Gabriely, I. (2001) The role of fat depletion in the biological benefits of caloric restriction. J. Nutr. 131:903–906.

    Google Scholar 

  13. Lindsay, D.G. (1999) Diet and Aging: The possible relation to reactive oxygen species. J. Nutr. Health Aging. 3, 77–83.

    Google Scholar 

  14. Nicolas, A.S., Lanzmann-Petithory, D. and Vellas, B. (1999) Caloric restriction and aging. J. Nutr. Health Aging. 3, 77–83.

    PubMed  CAS  Google Scholar 

  15. Landsberg, L. (1999) Weight reduction and obesity. Clin. Exp. Hyperten. 21, 763–768.

    CAS  Google Scholar 

  16. Scacchi, M., Pincelli, A.J. and Cavagni, F. (1999) Growth hormone in obesity. Int. J. Obes. Related Metab. Disorders. 23, 260–271.

    Article  CAS  Google Scholar 

  17. Shephard, R.J. and Sherk, P.N. (1998) Associations between physical activity and susceptibility to cancer, possible mechanisms. Sports. Med. 26, 293–315.

    Article  PubMed  CAS  Google Scholar 

  18. Levin, B.E. (2000) The Obesity epidemic: Metabolic imprinting on genetically susceptible neural circuits. Obes. Res. 8, 342–347.

    Article  PubMed  CAS  Google Scholar 

  19. Hermansen, K. (2000) Diet, blood pressure and hypertension, Br. J. Nutr. 83, 113–119.

    Article  Google Scholar 

  20. Ramaiah, S.K., Apte, U. and Mehendale, H.M. (2000) Diet restriction as a protective mechanism in non-cancer toxicity outcomes: A review. Int. J. Toxicol. 19, 413–424.

    Article  CAS  Google Scholar 

  21. Kari, F., Hatch, G., Slade, R., Crissman, K., Simeonova, P.P. and Luster, M. (1997) Dietary restriction mitigates ozone induced lung inflammation in rats: A Role for endogenous antioxidants. Am. J. Respir. Cell Mol. Biol. 17, 740–747.

    PubMed  CAS  Google Scholar 

  22. Feners, R.J., Duffy, P.H., Leykey, J.E.A., Turlutto, A., Mittelmaedi, R.A. and Hari, R.W. (1989) Effects of chronic caloric restriction on hepatic enzyme of intermediary metabolism in the male F344 rat. Mech. Ageing Dev. 48, 179–189.

    Article  Google Scholar 

  23. Leakey, J.E.A., Seng, J.E., Barnas, C.R., Baker, V.M. and Hart, R.W. (1998) A mechanistic basis for the beneficial effects of dietary restriction on longevity and disease. Consequences for the interpretation of rodent toxicity studies. Int. J. Toxicol 17, 5–56.

    CAS  Google Scholar 

  24. Duffy, P.H., Feuers, R.J., Pipkin, J.L., Berg, J.F., Leakey, J.E.A., Turturro, A. and Hart, R.W. (1995). The effects of dietary restriction and aging on the physiological response of rodents to drugs. In dietary restriction: Implications for the design and interpretation of toxicity and carcinogenecity studies Eds. Hart RW, Neumann DA, Robertson RT, ILSI Press, Washington DC, pp 127–140.

    Google Scholar 

  25. Aly, K.B., Pipkin, J.L., Hinson, W.G., Feuers, R.J., Duffy, P.H., Lyn Cook, L. and Hart, R.W. (1994) Chronic caloric restriction induces stress proteins in the hypothalamus of rat. Mech. Aging Dev. 76, 11–23.

    Article  PubMed  CAS  Google Scholar 

  26. Berg, T.F., Breen, P.J., Feuers, R.J., Oriaku, E.T., Chen, F.X. and Hart, R.W. (1994) Acute toxicity of ganciclovir, effects of dietary restriction and chronobiology. Food Chem. Toxicol. 32, 45–50.

    Article  PubMed  CAS  Google Scholar 

  27. Soll, A.H., Weinstein, W.M., Kurata, J. and McCarthy, D. (1991) Nonsteroidal anti inflammatory drugs and peptic ulcer disease. Ann. Intern. Med. 114, 307–319.

    PubMed  CAS  Google Scholar 

  28. Kauffman, G. (1989) Aspirin induced gastric mucosal injury: Lessons learned from animal models. Gastroenterology 96, 606–614.

    PubMed  CAS  Google Scholar 

  29. Lee, M. and Devi, B.G. (1996) Effects of dietary restriction on experimental gastric mucosal injury in Fischer 344 rats. Mech. Aging Dev. 89, 11–20.

    Article  PubMed  CAS  Google Scholar 

  30. Rao, S.B., Young, R.A. and Mehendale, H.M. (1989) Hepatic polyamines and related enzymes following chlordecone potentiated enzymes following chlordecone potentiated CC14 toxicity in rats. J. Biochem. Toxicol. 4, 55–63.

    Article  PubMed  CAS  Google Scholar 

  31. Rao, S.B. and Mehendale, H.M. (1989) Protective role of fructose 1,6-bisphosphate during CC14 hepatotoxicity in rats. Biochem. J. 262, 721–725.

    PubMed  CAS  Google Scholar 

  32. Rao, S.B. and Mehendale, H.M. (1989) Protection from chlordecone(kepone)-potentiated CC14 hepatotoxicity in rats by fructose 1,6-diphosphate. Int. J. Biochem. 21, 949–954.

    Article  PubMed  CAS  Google Scholar 

  33. Dajani, O.F., Refsnes, M., Guren, T.K., Horn, R.S., Thoresen, G.H. and Christoffersen, T. (1994) Elevated glucose concentrations inhibit DNA synthesis and expression of C-myc in cultured hepatocytes. Biochem. Biophys. Res. Commun. 202, 1476–1482.

    Article  PubMed  CAS  Google Scholar 

  34. Mehendale, H.M. (1991) Role of hepatocellular regeneration and hepatolobular healing in the final outcome of liver injury. A two stage model of hepatotoxicity. Biochem. Pharmacol. 42, 1155–1162.

    Article  PubMed  CAS  Google Scholar 

  35. Soni, M.G. and Mehendale, H.M. (1998) Role of tissue repair in toxicological interaction among hepatologic organics. Environ. Health Perspect. 106, 1307–1317.

    PubMed  CAS  Google Scholar 

  36. Calabrese, E.J. and Mehendale, H.M. (1996). A review of the role of tissue repair as an adaptive strategy: Why low doses are often non-toxic and high doses are fatal. Food Chem. Toxicol. 34, 301–311.

    Article  PubMed  CAS  Google Scholar 

  37. Mehendale, H.M. (1994) Amplified interactive toxicity of chemicals at non toxic levels: mechanistic considerations and implications to public health. Environ. Health Perspect. 10, 139–149.

    Google Scholar 

  38. Ramaiah, S.K., Soni, M.G., Seng, J., Leakey, J.E.A. and Mehendale, H.M. (1999). Molecular players in increased thioacetamide hepatic injury and decreased mortality following diet restriction. Toxicol. Sci. 48, 164–171.

    Google Scholar 

  39. Ramaiah, S.K., Warbritton, A., Bucci, T.J., Soni, M.G. and Mehendale, H.M. (1998). Temporal changes in tissue repair response permit survival of diet restricted rats from an acute lethal dose of thioacetamide. Mechanism of survival. Toxicol. Sci. 45, 233–241.

    CAS  Google Scholar 

  40. Soni, M.G., Ramaiah, S.K., Mumtaz, M.M., Clewell, H. and Mehendale, H.M. (1999). Toxicant inflicted injury and stimulated tissue repair are opposing toxicodynamic forces in predictive toxicology. Regul. Phamacol. Toxicol. 29, 165–174.

    Article  CAS  Google Scholar 

  41. Hart, R.W., Leakey, J., Duffy, P.H., Feuers, R.J. and Turturro, A. (1996). The effects of dietary restriction on drug testing and toxicity. Exp. Toxicol. Pathol. 48, 121–127.

    PubMed  CAS  Google Scholar 

  42. Barrett, J.C. (2000). Molecular and environmental causes of cancer. Drug Metab. Rev. 32, 139–142.

    Article  PubMed  CAS  Google Scholar 

  43. Klaunig, J.E. and Kamendulis, L.M. (1999). Mechanism of cancer chemoprevention in hepatic carcinogenesis: modulation of focal lesion growth in mice. Toxicol. Sci. 52, 101–106.

    PubMed  CAS  Google Scholar 

  44. Hikita, H., Vaughan, J., Babcock, K. and Pitot, H.C. (1999). Short term fasting and the reversal of the stage of promotion in rat hepatocarcinogenesis: role of cell replication, apoptosis and gene expression. Toxicol. Sci. 52, 17–23.

    PubMed  CAS  Google Scholar 

  45. Kritchevsky, D. (1999). Caloric restriction and experimental mammary carcinogenesis. Breast Cancer Res. Treat. 46, 161–167.

    Article  Google Scholar 

  46. Kritchevsky, D. (1997). Caloric restriction and experimental mammary carcinogenesis. Breast Cancer Res. Treat. 46, 161–167.

    Article  PubMed  CAS  Google Scholar 

  47. Yoshida, K., Inoue, T., Nojima, K., Hirabayashi, Y. and Sado, T. (1997). Caloric restriction reduces the incidence of myeloid leukemia induced by a single whole body radiation in C3H/He mice. Proc. Nat. Acad. Sci. 94, 2615–2619.

    Article  PubMed  CAS  Google Scholar 

  48. James, S.J. and Muskhellshvili, L. (1994). Rates of apoptosis and proliferation vary with caloric intake and may influence incidence of spontaneous hepatoma in C57BL/6xc3HFI mice. Cancer Res. 54, 5508–5510.

    PubMed  CAS  Google Scholar 

  49. Steinbach, G., Heymsfield, S., Olansen, N.E., Tighe, A. and Holt, P.R. (1994). Effect of caloric restriction on colonic proliferation in obese persons: Implications for colon cancer prevention. Cancer Res. 54, 1194–1197.

    PubMed  CAS  Google Scholar 

  50. Roebuck, B.D., Baumgartner, K.J. and MacMillan, D.L. (1993). Caloric restriction and intervention in pancreatic carcinogenesis in the rat. Cancer Res. 53, 46–52.

    PubMed  CAS  Google Scholar 

  51. Weindruch, R. and Sohal, R.S. (1997). Caloric intake and aging. N Engl. J. Med. 337, 986–994.

    Article  PubMed  CAS  Google Scholar 

  52. Duffy, P.H., Feuers, R.J., Leakey, J.E.A., Nakamura, K., Turturro, A. and Hart, R.W. (1989). Effect of chronic caloric restriction on physiological variables that modulate energy metbolism in the male Fischer-344 rat. Mech. Aging Dev. 48, 117–133.

    Article  PubMed  CAS  Google Scholar 

  53. Youngman, L.D. (1993). Protein restriction (PR) and caloric restriction (CR) compared: Effects of DNA damage, carcinogenesis and oxidative damage. Mutat. Res. 295, 165–179.

    PubMed  CAS  Google Scholar 

  54. Rogers, A.E., Zeisel, S.H. and Groopman, J. (1993). Diet and carcinogenesis. Carcinogenesis 14, 2205–2217.

    Article  PubMed  CAS  Google Scholar 

  55. Weindruch, R., Albanes, B. and Kritchevsky, D. (1991). The role of calories and caloric restriction in carcinogenesis. Hematol. Oncol. Clin. North Am. 5, 79–89.

    PubMed  CAS  Google Scholar 

  56. Krishnaswamy, K. and Polasa, K. (2001). Non-nutrients and cancer prevention. ICMR Bull 31, 1–9.

    Google Scholar 

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  1. Department of Biochemistry, Kasturba Medical College, 575 004, Bejai, Mangalore

    M. N. Astagimath & Shrinivas B. Rao

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Astagimath, M.N., Rao, S.B. Dietary restriction (DR) and its advantages. Indian J Clin Biochem 19, 1–5 (2004). https://doi.org/10.1007/BF02872379

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