Skip to main content
SpringerLink
Log in

Hepatocyte-matrix interaction

  • Papers From The Collagen Symposium
  • Published:
Proceedings / Indian Academy of Sciences Aims and scope Submit manuscript

Abstract

Various components of extracellular matrices have unique patterns of distribution in the liver, which change under hepatic regeneration and in pathological conditions.In vitro studies using isolated hepatocytes maintained in culture on different matrix proteins or tissue biomatrices revealed that the matrix influences the biochemical activity of hepatocytes in culture on a selective basis. Hepatocyte-matrix interactions are mediated by specific receptors for matrix proteins belonging to both integrin and non-integrin group of cell surface molecules. The level ofα 1 β 1 integrin, which is a common receptor for Col IV and Ln in liver appears to change under hepatic regeneration; cat ions appear to modulate its interaction with Col IV and Ln in a differential manner. A number of other integrin receptors including that for fibronectin (α 5 β 1) and vitronectin (α v β 1) are also present in liver. Apart from integrin receptors, non-integrin receptors such as 67 kDa laminin binding protein, 68 kDa collagen IV binding protein, 110 kDa Fn receptor are also present in liver cells. HSPG present on the hepatocyte surface also appears to have an augmenting effect in mediating cell adhesion. Although matrix components appear to exert their effect through interaction with matrix receptors on cell surface, details about the intracellular signalling process in liver cells are not clear.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hahn E, Wick G, Pencer D and Timpl R 1980Gut. 21 63

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Rojkind M and Ponce-Noyola P 1982Collagen Relat. Res. 2 1511

    Article  CAS  Google Scholar 

  3. Martinez-Hermandez A 1984Lab. Invest. 51 57

    Google Scholar 

  4. Clement B M, Rissel S, Peyrol Y, Mazurier Y, Grimaud J and Guillouzo A 1985J. Histochem. Cytochem. 33 407

    Article  CAS  PubMed  Google Scholar 

  5. Wishes M H and Evans W H 1975Biochem. J. 146 375

    Article  Google Scholar 

  6. Bartles J R, Braiterman L T and Hubbard A L 1985J. Biol. Chem. 260 12792

    Article  CAS  PubMed  Google Scholar 

  7. Enrich C, Evans W H and Gahamber C G 1988FEBS Lett. 228 135

    Article  CAS  PubMed  Google Scholar 

  8. Hughes R C and Stamatoglou S C 1987J. Cell. Sci. 8 273

    Article  CAS  Google Scholar 

  9. Prinz R, Klein U, Sudhakaran P R, Sinn W, Ullrich K and von Figura K 1980Biochem. Biophys. Acta 630 402

    Article  CAS  PubMed  Google Scholar 

  10. Sudhakaran P R, Anil Kumar N and Santhosh A 1997 InLiver and environmental xenobiotics (eds) Rana and Taketa (New Delhi: Narosa) pp. 1–17

    Google Scholar 

  11. Rojkind M, Gatmaitan Z, Mackensan S, Giambrone M A, Proce P and Reid L M 1980J. Cell Biol. 87 255

    Article  CAS  PubMed  Google Scholar 

  12. Dunn J C Y, Tompkins R G and Yarmush M L 1992J. Cell Biol. 116 1043

    Article  CAS  PubMed  Google Scholar 

  13. Ben-Ze’ev A and Amsterdam A 1986Proc. Natl. Acad. Sci. USA 83 2894

    Article  PubMed  PubMed Central  Google Scholar 

  14. Sudhakaran P R, Stamatoglou S C and Hughes R C 1986Exp. Cell Res. 167 505

    Article  CAS  PubMed  Google Scholar 

  15. Ben-Zeev A, Robinson G S, Bucher N L R and Farmer S R 1988Proc. Natl. Acad. Sci. 85 2161

    Article  CAS  PubMed  Google Scholar 

  16. Santhosh A, Mathew S and Sudhakaran P R 1998Indian J. Biochem. Biophys. 35 200

    CAS  PubMed  Google Scholar 

  17. Emi Y, Chijiwa C and Omura T 1990Proc. Natl. Acad. Sci. USA 87 9746

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Nakamura T, Teramoto H, Tomita Y and Ichihara A 1984Biochem. Biophys. Res. Commun. 122 884

    Article  CAS  PubMed  Google Scholar 

  19. Wakimoto H and Oka T 1983J. Biol. Chem. 258 3775

    Article  CAS  PubMed  Google Scholar 

  20. Streuli C H, Bailey N and Bissell M J 1991J. Cell. Biol. 115 1383

    Article  CAS  PubMed  Google Scholar 

  21. Howlett A R and Bissell M J 1993Epithelial Cell Biol. 2 79

    CAS  PubMed  Google Scholar 

  22. Lin C R and Bissell M J 1993FASEB. J. 7 737

    Article  CAS  PubMed  Google Scholar 

  23. Werb S, Tremble P M, Behrendisen O, Crowley E and Damsky C H 1989J. Cell Biol. 109 877

    Article  CAS  PubMed  Google Scholar 

  24. Juliano R L and Haskill S 1993J. Cell Biol. 120 577

    Article  CAS  PubMed  Google Scholar 

  25. Hay E 1991Cell biology of extracellular matrix (New York: Plenum)

    Book  Google Scholar 

  26. Akiyama S K, Nagata K and Yamada K M 1990Biochem. Biophys. Acta 31 91

    Google Scholar 

  27. Albelda S M and Buck C A 1990FASEB J. 4 2868

    Article  CAS  PubMed  Google Scholar 

  28. Damsky C H and Werb Z 1992Curr. Opin. Cell Biol. 4 772

    Article  CAS  PubMed  Google Scholar 

  29. Ruoslahti E 1991J. Clin. Invest. 87 1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Hynes R O 1992Cell 69 11

    Article  CAS  PubMed  Google Scholar 

  31. Sonnenberg A 1993Curr. Top. Microbiol. Immunol. 184 7

    CAS  PubMed  Google Scholar 

  32. Sastry S K and Horwitz A F 1993Curr. Opin. Cell Biol. 5 819

    Article  CAS  PubMed  Google Scholar 

  33. Nermut M V, Green N M, Eason P, Yamada S S and Yamada K M 1988EMBO J. 7 4093

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Dustin M L and Springer J A 1989Nature (London) 341 619

    Article  CAS  PubMed  Google Scholar 

  35. Guo M, Toda K and Grinnell F 1990J. Cell Sci. 96 197

    Article  CAS  PubMed  Google Scholar 

  36. Kim L J, Ishihara S, Lee C C, Akiyama S K, Yamada K M and Grinnell F 1992J. Cell Sci. 103 743

    Article  CAS  PubMed  Google Scholar 

  37. Ruoslahti E and Pierschbacher M D 1987Science 238 491

    Article  CAS  PubMed  Google Scholar 

  38. Ruoslahti E 1988Annu. Rev. Biochem. 57 375

    Article  CAS  PubMed  Google Scholar 

  39. Guan J L and Hynes R O 1990Cell 60 53

    Article  CAS  PubMed  Google Scholar 

  40. D’Souza S E, Ginsberg M H, Burke J A and Plow E F 1990J. Biol. Chem. 265 3440

    Article  PubMed  Google Scholar 

  41. Loftus J C, O’Toole T E, Plow E F, Glass A, Frelinger A L and Ginsberg M H 1990Science 249 915

    Article  CAS  PubMed  Google Scholar 

  42. Smith J W and Cheresh D A 1990J. Biol. Chem. 265 2168

    Article  CAS  PubMed  Google Scholar 

  43. Calvete J J, Mann K, Schafer W, Fernandez-Lafuente R and Gulsan J M 1994Biochem. J. 298 1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Plow E F, D’Souza S E and Ginsberg M H 1992Semin. Thromb. Homost. 18 324

    Article  CAS  Google Scholar 

  45. D’Souza S E, Ginsberg M H, Matsueda G R and Plow E F 1991Nature (London) 350 66

    Article  PubMed  Google Scholar 

  46. Randi A M and Hogg N 1994J. Biol. Chem. 269 12395

    Article  CAS  PubMed  Google Scholar 

  47. Stanley P, Bates P A, Harvey J, Bennelt R L and Hogg N 1994EMBO J. 13 1790

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Fox J E B, Lipfert L, Clark E A, Renolds C C, Austin C D and Brugge J S 1993J. Biol. Chem. 268 25973

    Article  CAS  PubMed  Google Scholar 

  49. Schwartz M A, Schaller M D and Ginsberg M H 1995Annu. Rev. Cell Dev. Biol. 11 549

    Article  CAS  PubMed  Google Scholar 

  50. Otey C A, Paralko F M and Burridge K 1990J. Cell Biol. 111 721

    Article  CAS  PubMed  Google Scholar 

  51. Burridge K, Fath K, Kelly J, Nuckolls G and Turner C 1988Annu. Rev. Cell Biol. 4 487

    Article  CAS  PubMed  Google Scholar 

  52. Ingber D E and Folkman J 1989Cell 58 803

    Article  CAS  PubMed  Google Scholar 

  53. Ingber D ECurr. Opin. Cell Biol. 3 841

  54. Kornberg L J, Earp H S, Turner C E, Prockop C and Juliano R L 1991Proc. Natl. Acad. Sci. USA 88 8392

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Guan J L and Shalloway D 1992Nature (London) 358 690

    Article  CAS  PubMed  Google Scholar 

  56. Clark E A, Shattil S J, Ginsberg M H, Bolden J and Brugge J J 1994J. Biol. Chem. 269 28859

    Article  CAS  PubMed  Google Scholar 

  57. Berton G, Fumagalli L, Lay danna C and Sorio C 1994J. Cell Biol. 126 1111

    Article  CAS  PubMed  Google Scholar 

  58. Chen Q, Kinch M S, Lin T H, Burridge K and Juliano R L 1994J. Biol. Chem. 269 26602

    Article  CAS  PubMed  Google Scholar 

  59. Morino N, Mimura T, Hamasaki K, Tobe K, Ueki K, Kikuchi K, Takehara K, Kadowaki J, Yazal Y and Nojima Y 1995J. Biol. Chem. 270 269

    Article  CAS  PubMed  Google Scholar 

  60. Miyamoto S, Teramoto H, Coso O A, Gutkind J J, Burbelo P D, Akiyama S K and Yamada K M 1995J. Cell Biol. 131 791

    Article  CAS  PubMed  Google Scholar 

  61. Fox J E B, Goll D E, Reynolds L C and Philips D R 1985J. Biol. Chem. 260 1060

    Article  CAS  PubMed  Google Scholar 

  62. Banga H S, Simon E R, Brass L F and Rittenhouse S E 1986Proc. Natl. Acad. Sci. USA 83 9197

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Zhang J, Fry M J, Waterield M D, Jaken S, Laao L, Fox J E B and Rittenhouse S E 1992J. Biol. Chem. 267 4686

    Article  CAS  PubMed  Google Scholar 

  64. Miyauchi A, Alvarez J, Grenfield E M, Teti A, Grano M, Colucci S, Zambonin-Zallon A, Ross F P, Teitelbaum S L and Cheresh D 1991J. Biol. Chem. 266 20369

    Article  CAS  PubMed  Google Scholar 

  65. Menon R P, Pillai S and Sudhakaran P R 1993Biochem. Mol. Biol. Int. 31 833

    CAS  PubMed  Google Scholar 

  66. Nathan C and Sanchez E 1990J. Cell Biol. 111 2171

    Article  CAS  PubMed  Google Scholar 

  67. Ng-sikorski J, Anderson R, Patarroyo M and Anderson T 1991Exp. Cell Res. 195 504

    Article  CAS  PubMed  Google Scholar 

  68. Schwartz M A and Denninghoff K 1994J. Biol. Chem. 269 11133

    Article  CAS  PubMed  Google Scholar 

  69. Schwartz M A 1993J. Cell Biol. 120 1003

    Article  CAS  PubMed  Google Scholar 

  70. Lindberg F P, Gresham H D, Schwarz E and Brown E J 1993J. Cell Biol. 123 485

    Article  CAS  PubMed  Google Scholar 

  71. Bissel D M, Stamatoglou S C, Nermut M V and Hughes R C 1985Eur. J. Cell Biol. 40 72

    Google Scholar 

  72. Johansson S and Höök M 1984J. Cell Biol. 98 810

    Article  CAS  PubMed  Google Scholar 

  73. Johansson S, Kjellen L, Höök M and Timpl R 1981J. Cell Biol. 90 260

    Article  CAS  PubMed  Google Scholar 

  74. Timpl R, Johansson S, Van Deldin V, Oberbaumer L and Höök M 1983J. Biol. Chem. 258 8922

    Article  CAS  PubMed  Google Scholar 

  75. Rubin K, Höök M, Obrink B and Timpl R 1981Cell 24 463

    Article  CAS  PubMed  Google Scholar 

  76. Reid L M and Jefferson D M 1983Hepatology 4 548

    Article  Google Scholar 

  77. Rojkind M, Gatmaitan Z, Mackensen S, Giambrone M A, Proce P and Reid L M 1980J. Cell Biol. 87 255

    Article  CAS  PubMed  Google Scholar 

  78. Gullberg D, Terracio L, Borg T K and Rubin K 1989J. Biol. Chem. 264 12686

    Article  CAS  PubMed  Google Scholar 

  79. Forsberg E, Paulsson M, Timpl R and Johansson S 1990J. Biol. Chem. 265 6376

    Article  CAS  PubMed  Google Scholar 

  80. Gullberg D, Turner D C, Borg T K, Terracio L and Rubin K 1990Exp. Cell Res. 190 254

    Article  CAS  PubMed  Google Scholar 

  81. Stamatoglou S C, Bawumia S, Johansson S, Forsberg E and Hughes R C 1991FEBS Lett. 288 241

    Article  CAS  PubMed  Google Scholar 

  82. Ruoslahti E 1988Annu. Rev. Cell Biol. 3 179

    Google Scholar 

  83. Johansson S, Forseberg E and Lundgreen B 1987J. Biol. Chem. 262 7819

    Article  CAS  PubMed  Google Scholar 

  84. Stamatoglou S C and Hughes R C 1994FASEB J. 8 420

    Article  CAS  PubMed  Google Scholar 

  85. Stamatoglou S C, Ge R C, Mills G, Butters T D, Zaide F and Hughes R C 1990J. Cell Biol. 111 2117

    Article  CAS  PubMed  Google Scholar 

  86. Stamatoglou S C, Enrich C, Manson M M and Hughes R C 1992J. Cell Biol. 116 1507

    Article  CAS  PubMed  Google Scholar 

  87. Volpes R, Van Deen Oord J J and Desmet V J 1993Am. J. Pathol. 142 1483

    CAS  PubMed  PubMed Central  Google Scholar 

  88. Sudhakaran P R, Kumar N A and Menon B 1997Gluconjugate J. 14 S76

  89. Clement B, Segui Beat B, Savangner P, Kleinman H K and Yamada Y 1990J. Cell Biol. 110 185

    Article  CAS  PubMed  Google Scholar 

  90. Anil Kumar N and Sudhakaran P R 1993Biochem. Mol. Biol. Int. 31 201

    Google Scholar 

  91. Hook M, Kjellen L, Johansson S and Robinson J 1984Annu. Rev. Biochem. 53 847

    Article  CAS  PubMed  Google Scholar 

  92. Bernfield M and Sanderson R D 1990Philos. Trans. R. Soc. London 327 171

    CAS  Google Scholar 

  93. Yamada K M 1983Annu. Rev. Biochem. 52 761

    Article  CAS  PubMed  Google Scholar 

  94. Takeichi M 1990Annu. Rev. Biochem. 59 237

    Article  CAS  PubMed  Google Scholar 

  95. Obrink B 1991BioEssays 13 227

    Article  CAS  PubMed  Google Scholar 

  96. Volpes R, Van den Oord J J and Demet V J 1990Hepatology 12 59

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Kerala, 695 581, Kariavattom, Trivandrum, India

    P R Sudhakaran

Authors
  1. P R Sudhakaran
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P R Sudhakaran.

Additional information

This paper was part of the collagen symposium organized on the occasion of the Golden Jubilee of the Central Leather Research Institute, Chennai in January 1999.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sudhakaran, P.R. Hepatocyte-matrix interaction. Proc. Indian Acad. Sci. (Chem. Sci.) 111, 331–342 (1999). https://doi.org/10.1007/BF02871913

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02871913

Keywords

Search

Navigation