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Liver system. III

Prototype to study its unstable equilibrium on human biopsy samples

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Research in Clinic and Laboratory

Summary

Autoisodiasostasis of the liver, i.e., its self-maintenance without change over the course of time, is characterized by a bistable equilibrium between two extreme phases called homopoiesis, during which the liver system repairs its worn structures and replicates its cells, and homeorhesis, during which it satisfies the body’s needs. Albumin traffic through the hepatocyte, rendered visible by means of an immunohistological method, has been used as a prototype model to study the dynamics of autoisodiasostasis. An account is given of the oscillation of autoisodiasostasis between homopoiesis and homeorhesis through two intermediate phases. The phase cycle of autoisodiasostasis is illustrated in the form of atemporal bidimensional and tridimensional diagrams. The temporal behavior of the system is represented as a helix trajectory obtained by the projections of homopoiesis-homeorhesis phase cycle on time series.

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Authors and Affiliations

  1. Istituto di Medicina Interna, Scuola di Specializzazione in Malattie del Fegato e del Ricambio, Università degli Studi di Milano, Italia

    Nicola Dioguardi

  2. Centro di Medicina Teoretica, Università degli Studi di Milano, sponsorizzato dalla MESA, Italia

    Nicola Dioguardi

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  1. Nicola Dioguardi
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Additional information

This paper forms part of research on pre-cancer states of the liver system, financed by theAssociazione Italiana per la Ricerca sul Cancro (AIRC), Milan and by theOspedale Maggiore — Istituto Scientifico di Ricovero e Cura — Milan.

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Dioguardi, N. Liver system. III. Res. Clin. Lab. 19, 307–326 (1989). https://doi.org/10.1007/BF02871820

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  • DOI: https://doi.org/10.1007/BF02871820

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