Abstract
The stimulating effect of ascorbic acid, administered to colchicine-treated mycelia ofCunninghamella elegans, on respiration, keto acid production and carbohydrate accumulation was lower than the highly increased rate of sugar absorption. Furthermore, the increasing ascorbic acid concentration in colchicine media favoured lower carbohydrate accumulation, keto acid production, carbon dioxide output and highly stimulated the utilization of the absorbed sugars for the formation of non-carbohydrate compounds. In addition, the vitamin seemed to counteract the inhibitory effects of colchicine on nucleoprotein and soluble nucleotide synthesis by colchicine-treated mycelia particularly when the drug was administered at high levels.
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Naguib, M.I. Interaction of ascorbic acid and colchicine with sucrose utilization byCunninghamella elegans . Folia Microbiol 13, 190–196 (1968). https://doi.org/10.1007/BF02871033
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DOI: https://doi.org/10.1007/BF02871033