Abstract
The effect of streptomycin on the number of cells involved in immunogenesis during the first ten days after antigenic stimulation was studied in relation to the dose of streptomycin. The results were read by means of Jerne and Nordin’s plaque technique, as modified by Šterzl. In dozes of 0.05, 0.1 and 0.5 mg, streptomycin had practically no effect on antibody production. On raising the dose to 1 mg, and particularly to 5 mg, the number of immunologically competent cells which received antigenic stimulation was markedly reduced. The difference between the number of plaque-forming cells in mice treated with 5 mg streptomycin and in the controls is statistically significant (P<0.05).
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Toshkov, A., Slavcheva, E. Effect of streptomycin on antibody-producing cells in the spleen of albino mice. Folia Microbiol 13, 177–179 (1968). https://doi.org/10.1007/BF02871031
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DOI: https://doi.org/10.1007/BF02871031