Abstract
From the yeastCandida utilis a compound was isolated which uncouples the process of cell growth and division by accelerating the cell division without influencing outgrowth of cell mass when applied on another population of identical yeasts. This compound accelerated the initiation of DNA synthesis and had no influence on the synthesis of RNA and protein. Moreover, in the presence of division inducing factor the yeasts started multiplication before the content per cell reached the control level. The stimulating effect of division inducing factor was not obvious when the proteosynthesis of yeast cells was inhibited. We concluded that the division inducing factor regulates the formation of a protein which is synthesized in a very small amount and has a role in the initiation of DNA replication.
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Vraná, D. Synthesis of macromolecules in the yeastCandida utilis as influenced by a specific factor inducing cell division. Folia Microbiol 15, 253–258 (1970). https://doi.org/10.1007/BF02869051
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DOI: https://doi.org/10.1007/BF02869051