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It was found in a study of the hydroxylating capacity of one of theFungi imperfecti, the genusBeauveria, some of the species of which are able to introduce the oxygen function into position 11α of various steroid compounds, that the enzyme activity ofBeauveria globulifera gives rise both to the corresponding 11α-hydroxy-derivative and to the 5β-saturated 11α-hydroxy-compound or a 5β-saturated 7β,11α-dihydroxy-compound. The isolation and the identification of the products of biotransformation of some steroids of the pregnane and androstane series byBeauveria globulifera is described.
KeywordsPregnane Beauveria Bassiana Steroid Compound Crude Mixture Biotransformation Reaction
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- Čapek, A., Hanč, O., Tadra, M., Tůma, J.:An improved preparation of cortisone from cortexolone. (In Czech). Čs. farm. 15: 198, 1966a.Google Scholar
- Čapek, A., Hanč, O., Tadra, M., Tůma, J.:The effect of substituents on the direction of the transformation of steroids by Beauveria bassiana. Fol. microbiol. 11: 159, 1966b.Google Scholar
- Černý, V.:Chemistry of steroid compounds. Publ. House of the Czechosl. Acad. Sciences, Prague 1960, p. 152, 176.Google Scholar
- Ilavsky, J., Herzog, H. L.:11.-Hydroxylation of steroids by Beauveria. U.S. pat. 3,013,945, 1961.Google Scholar
- Meister, P. D., Weintraub, A.:11α-Hydroxylation of steroids by Sporotrichum. U.S. pat. 2,877,162, 1959.Google Scholar
- Pasqualini, J. R.:Transformation chimique des steroides par l'action de micro-organismes. Ann. Chim. Paris 8: 27, 1963.Google Scholar
- Protiva, J., Martínková, J., Schwarz, V., Syhora, K.:Microbiol. transformation of steroid comp unds of the pregnane type substituted in positions 16 and 17. Fol. microbiol. 13: 146, 1968.Google Scholar
- Schwarz, V., Martínková, J., Protiva, J., Syhora, K.:Microbial 7β, 11α-dihydroxylation of steroids. Collection Czech. Chem. Comm. 31: 4703, 1966.Google Scholar
- Syhora, K., Mazáč, R.:A novel synthesis of 16-methylene-17α-acetoxy-20-ketopregnane derivatives. Collection Czech. Chem. Commun. 29: 2351, 1964.Google Scholar