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Antimicrobial agents

XVIII. Inducible resistance in species of the genusCandida

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Abstract

The development of acquired, temporary resistance induced by an adaptation mechanism as a result of direct contact of the cell with an antimycotic, was demonstrated in pathogenic species of the genusCandida. Acquired resistance induced by one substance was manifested in multiresistance to other, structurally quite different, antimycotics. Cultivation of the strain on antimycotic-free medium led to relatively rapid deadaptation and the strain regained its initial sensitivity. The sensitivity of adapted and deadapted strains was studied by the dilution method (determining MIC values) and by the “direct” Warburg method (evaluating metabolic quotients).

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Authors and Affiliations

  1. Institute of Pharmacy and Biochemistry, Prague 3

    A. Čapek, A. Šimek & J. Kejda

  2. Clinic of Skin and Venereal Diseases, Faculty of Medical Hygiene, Charles University, Prague 2

    A. Čapek, A. Šimek & J. Kejda

Authors
  1. A. Čapek
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  2. A. Šimek
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  3. J. Kejda
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Čapek, A., Šimek, A. & Kejda, J. Antimicrobial agents. Folia Microbiol 18, 304–307 (1973). https://doi.org/10.1007/BF02868047

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  • DOI: https://doi.org/10.1007/BF02868047

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