Abstract
Studies of the nutritional requirements of a neomycin-producing mutantStreptomyces fradiae H developed by the authors show that tapioca starch (at a concentration of 5%) is an excellent carbon source for antibiotic production while soya flour and yeast powder are superior nitrogen sources for neomycin production. A mixture of 1% soya flour and 1% yeast powder gives maximal antibiotic titer.
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References
Gruborskaya O. Z., Levitov M. M.: Some physiological characteristics ofActinomyces fradiae. (In Russian)Antibiotiki 8, 705 (1963).
Majumdar M. K., Majumdar S. K.: Utilization of carbon and nitrogen-containing for neomycin production byStreptomyces fradiae.Appl. Microbiol. 16, 744 (1967).
Majumdar M. K., Majumdar S. K.: Relationship between alkaline phosphatase and neomycin formation inStreptomyces fradiae.Biochem. J. 122, 393 (1971).
Šebek O. K.: The synthesis of neomycin −C14 byStreptomyces fradiae.Arch. Biochem. Biophys. 67, 71 (1955).
Waksman S. A., Lechevalier H. A.: Neomycin, a new antibiotic active against streptomycin resistant bacteria including the tuberculosis organism.Science 109, 305 (1949).
Nutrient medium for neomycin production.British Patent No. 788, 972, Feb 9, (1958).
Fermentation media for industrial fermentation with amylopectin as sole carbohydrate source.U.S. Patent No. 3,352,761 November 14 (1967).
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Bhadra, R., Goswami, S.K. & Majumdar, S.K. Effect of different complex nutrients on neomycin production byStreptomyces fradiae H. Folia Microbiol 18, 300–303 (1973). https://doi.org/10.1007/BF02868046
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DOI: https://doi.org/10.1007/BF02868046