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Nedocromil sodium in two models of conjunctival immediate hypersensitivity

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Abstract

The effects of intravenous administration of nedocromil sodium were investigated in active and passive models of conjunctival immediate hypersensitivity in rats. In the active sensitization model, animals were immunized with ovalbumin 21 days prior to ocular instillation of a solution containing ovalbumin. Nedocromil sodium administered prior to antigen challenge significantly inhibited emergence of conjunctival edema and erythema (P < .05) and reduced mast cell degranulation (P < .02). In the passive-sensitization model, the conjunctiva in one eye was injected with ovalbumin antiserum 48 hours prior to intravenous administration of ovalbumin. Nedocromil sodium administered prior to antigen challenge significantly and dose-dependently reduced appearance of the signs of conjunctivitis (P < .01) as well as vascular leakage (P < .05). These data indicate that intravenous nedocromil sodium is effective in animal models of allergic conjunctivitis and may have potential for wider therapeutic application. These data are also consistent with results of clinical studies in which nedocromil sodium relieved symptoms of allergic conjunctivitis and further support a role for nedocromil sodium in the prevention of allergic conjunctivitis.

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References

  1. Doherty MJ, Easty DL. Inflammatory and immunological cell profiles in a rat model of conjunctival immediate hypersensitivity.Clin Exp Allergy. 1989; 19: 449–455.

    Article  PubMed  CAS  Google Scholar 

  2. Levine BB, Vaz NM. Effect of combinations of inbred strain, antigen, and antigen dose on immune responsiveness and reagent production in the mouse. A potential mouse model for immune aspects of human atopic allergy.Int Arch Allergy Appl Immunol. 1970; 39: 156–171.

    PubMed  CAS  Google Scholar 

  3. Layton GT, Stanworth DR. The quantitation of IgG4 antibodies to three common food allergens by ELISA with monoclonal anti-IgG4.J Immunol Methods. 1984; 73: 347–356.

    Article  PubMed  CAS  Google Scholar 

  4. Udaka K, Takeuchi Y, Movat HZ. Simple method for quantitation of enhanced vascular permeability.Proc Soc Exp Biol Med. 1970; 133: 1384–1387.

    PubMed  CAS  Google Scholar 

  5. Dahlen SE, Bjorck T, Kumlin M, et al. Dual inhibitory action of nedocromil sodium on antigeninduced inflammation.Drugs. 1989; 37(suppl 1): 63–68.

    Article  PubMed  CAS  Google Scholar 

  6. Kjellman NI, Stevens MT. Clinical experience with Tilavist: an overview of efficacy and safety.Allergy. 1995; 50: 14–22.

    Article  PubMed  CAS  Google Scholar 

  7. Alexander M. Comparative therapeutic studies with Tilavist.Allergy. 1995; 50: 23–29.

    Article  PubMed  CAS  Google Scholar 

  8. Verin P. Treating severe eye allergy.Clin Exp Allergy. 1998; 28 (suppl 6): 44–48.

    Article  PubMed  Google Scholar 

  9. Merayo-Lloves J, Zhao TZ, Dutt JE, Foster CS. A new murine model of allergic conjunctivitis and effectiveness of nedocromil sodium.J Allergy Clin Immunol. 1996; 97: 1129–1140.

    Article  PubMed  CAS  Google Scholar 

  10. Calonge M, Montero JA, Herreras JM, Juberias JR, Pastor JC. Efficacy of nedocromil sodium and cromolyn sodium in an experimental model of ocular allergy.Ann Allergy Asthma Immunol. 1996; 77: 124–130.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, University of Bristol, Bristol, England

    Lindsay E. V. McGrath, M. J. Doherty & David L. Easty

  2. RPR Pharmaceuticals, 500 Arcola Rd., P.O. Box 1200, Mailstop 3C81, 19426, Collegeville, PA

    Alan Norris Ph.D.

Authors
  1. Lindsay E. V. McGrath
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  2. M. J. Doherty
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  3. David L. Easty
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  4. Alan Norris Ph.D.
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McGrath, L.E.V., Doherty, M.J., Easty, D.L. et al. Nedocromil sodium in two models of conjunctival immediate hypersensitivity. Adv Therapy 17, 7–13 (2000). https://doi.org/10.1007/BF02868026

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