Abstract
In the present study which was aimed to see the effect of zinc on pentylenetetrazole induced convulsive threshold in rats we found that zinc sulfate 100 μg intracerebroventricularly) and pentylenetetrazole (50 mg/kg intraperitoneally) produced dose related seizure activity; however, pretreatment with zinc decreased the threshold, increased the severity, incidence of multiple seizures and total duration of pentylenetetrazole induced seizures. Diazepam (5 mg/kg intraperitoneally) pretreatment increased the threshold and lowered the incidence of convulsions in zinc induced seizures which further confirms that the convulsive effect of zinc is through inhibition of gamma aimino butyric acid.
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Purpura, D.P., Penry, J.K., Tower, D.B., Woodbury, D.M. and Walter, R.D. (1972) Experimental models of epilepsy. Raven Press, New York.
Noble, E.P., Wurtman, R.T. and Axelrod, J. (1967) A simple and rapid method for injection of H3-norepinephrine into the lateral ventricle of the rat brain. Life Sciences. 6, 281–291.
Pei, Y.Q. and Koyama, I. (1986) Features of seizures and behavioural changes induced by intrahippocampal injection of zinc sulfate in the rabbit: a new experimental model of epilepsy. Epilepsia. 27(3), 183–188.
Rosen, A.D. and Frumin, N.V. (1979) Focal epileptogenesis after intracortical haemoglobin injection. Experimental Neurology, 66, 277–284.
Reid, S.A., Sypert, G.W. and Goggs, W.M. (1979) Histopathology of the ferri-induced chronic epileptic focus in cat. Exp. Neurol. 66, 205–210.
Lange, S.C., Nealsey, E.J. and Wyler, A.R. (1980) Neuronal activity in chronic ferric chloride epileptic foci in cats and monkeys. Epilepsia. 21, 251–254.
Willmore, I.J. (1978) Recurrent seizure induced by cortical iron injection, a model of post-traumatic epilepsy. Ann. Neurol. 4, 329–333.
Pei, Y. and Xie, S. (1980) A new experimental model of epilepsy. Yao Hsuch Hsuch Pao. 15, 113–117.
Tokuoka, S. (1967) Neurochemical consideration on the alleviating effect of caudal resection of the pancreas on epileptic seizure relationship of zinc metabolism to brain excitability. Bull Yamaguchi Med. Sch. 14, 1–18.
Alley, N.C., Killam, E.K. and Fisher, G.I. (1981) The influence of D-penicillamine treatment upon seizure activity and trace metal state in the Senegalese baboon, Papio papio. J. Pharmacol. Exp. Ther. 217, 138–146.
Papavasiion, P.S., Kutt, M., Miller, S.T., Rosal, V., Wang, Y.Y. and Aronson, R.B. (1979) Seizure disorders and trace metal, manganese tissue levels in treated epileptics. Neurology. 29, 1466–1479.
Pei, Y.Q., Zhao, D., Haung, J. and Cao, L. (1983) Zinc-induced seizures: a new experimental model of epilepsy. Epilepsia. 24, 169–176.
Mares, P. and Schickerova, R. (1980) Seizures elicited by subcutaneous injection of Metrazole during ontogenesis in rats. Act. Nerv. Super. 22, 264–268.
Lacoste, L. and Bartolucci, S. (1987) Pentylenetetrazole inhibits glutamate dehydrogenase and aspartate aminotransferase, and stimulates GABA aminotransferase in homogenates from rat cerebral cortex. Can. J. Physiol. Pharmacol. 66, 1135–1138.
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Khanna, N., Garg, A., Sharma, K.K. et al. Modulation of convulsive threshold of pentylene tetrazole by zinc. Indian J Clin Biochem 12, 86–90 (1997). https://doi.org/10.1007/BF02867963
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DOI: https://doi.org/10.1007/BF02867963