Abstract
The present study was done to assess the levels of glycoconjugates and ceruloplasmin in sera of patients with cervical cancer. Serum hexoses, hexosamines, sialic acid and fucose are elevated in a variety of inflammatory and neoplastic conditions. All the glycoconjugates, except fucose were increased in serum of patients compared to controls. Also, hexoses and sialic acid levels were high in patients with later stages of cancer compared to patients with early stage disease (P=<0.0001, P=0.03). Serum ceruloplasmin was increased in patients with early stage cancer (51.5mg/dl) and with late stage cancer (61mg/dl) compared to controls (38mg/dl). The elevated glycoconjugates may be the result of inflammatory reaction associated with neoplasia, as serum ceruloplasmin (an acute phase reactant) is also increased in these patients.
Similar content being viewed by others
References
Henry R.J., Cannon, D. C. and Winkelman JW. (1974); Clinical Chemistry: Principles and Techniques Harper and Row publishers Inc. pg 461
Bhuvarahamurthy, V., Balasubramanian, N., Vijaykumar, S. and Govindasamy, S. (1995) Effect of radiation on serum glycoproteins and glycosidases in patients with cervical carcinoma. Int. J. Gynaecol Obstet 48 49–54
Walker, C. and Gray, BN. (1986) Acute phase reactant proteins and carcinoembryonic antigen in cancer of colon and rectum. Cancer 52, 150–154
Krishnamurthy, S. and Jaya, S. (1986) Serum tocopherol, lipo-peroxides, ceruloplasmin and red cell glutathione and antioxidant enzymes in patients with oral cancer. Indian J. Cancer 23, 36–42
Winzler, RJ. Determination of serum glycoproteins. Methods of Biochemical Analysis; Vol 2; Ed. Glick D; pg. 279–311
Ravin, HA. (1961) An improved colorimetric enzymatic assay of ceruloplasmin. J. Lab. Clin. Med. 58, 161–8
Erbil, K. M., Jones J. D. and Klee, GG. (1985) Use and limitations of serum total and lipid bound sialic acid concentration as markers of colorectal cancer. Cancer 55, 404–409
Balasubramaniyan, N., Subramanian, S., Sekar, N., Bhuvarahamurthy, V. and Govindasamy, S. (1994) Diagnostic and prognostic role of plasma and urinary sialic acid in human carcinoma of uterine cervix. Biochem. Mol. Biol. Int. 33, 617–23
Bathi, R. J., Nandimath, K., Kannan, N. and Shetty, P. (2001) Evaluation of glycoproteins as prognosticators in head and neck malignancy. Indian J Dent Res. 12: 93–99
Berbee, H., Paszkowska, A., Siwek, B., Gradziel, K. and Cybulski, M. (1999) Total serum sialic acid concentration as a supporting marker of malignancy in ovarian neoplasia. Eur. J. Gynaecol, Oncol, 20, 389–392
Patel, P.S., Rawal, G. N. and Balar, D.B. (1993) Importance of serum sialic acid and lactate dehydrogenase in diagnosis and treatment monitoring of cervical cancer patients. Gynaecol. Oncol. 50, 294–299
Bandlish, U., Prabhakar, B. R. and Virmani (1991) U. Serum fucose levels in gynecological disorders including carcinoma cervix. Journal Indian Med. Assoc. 89, 250–251
Sen, U., Guha, S. and Chowdhury, J. R. (1985) A study of the prognostic role of serum fucose and fucosyl transferase in cancer of uterine cervix. Acta Med. Okayama 39, 125–30
Rao, V. R., Krishnamoorthy, L., Kumaraswamy, S. V. and Ramaswamy, G. (1998) Circulating levels in serum of total sialic acid, lipid associated sialic acid and fucose in precancerous lesions and cancer of the oral cavity. Cancer Detect. Prev. 22, 237–240
Fernandez-Rodriguez, J., Paez de la Cadena, M., Martinez-Zorzano, V. S. and Rodriguez-Berrocal, F. J. (1997) Fucose levels in sera and in tumours of colorectal adenocarcinoma patients. Cancer Lett. 121, 147–153
Agroyannis, B., Dardoufas, C., Vitoratos, N., Tzanatos, H., Kouvaris, J., Damatapoulas, A., Koutsikos, D., Dalamangas, A. and Papavasiliou, C. (1994) Changes in serum transferrin and ceruloplasmin after radiation therapy in women with cervical or uterine carcinoma. Clin. Exp. Obstet. Gynaecol. 21, 24–27.
Arumanayagam, M., Wong, F. W., Rogers, M. and Swaminathan, R. (1993) Serum ceruloplasmin, plasma copper concentration and copper to ceruloplasmin ratio in cervical carcinoma. Gynaecol. Obstet. Invest. 35, 175–178.
Chan, A., Wong, F. and Arumanayagam, M. (1993) Serum ultrafilterable copper, total copper and ceruloplasmin concentration in gynaecologic carcinomas. Ann. Clin. Biochem. 30, 545–549.
Hansen, J. S., Iversen, J., Limhe, A. and Bog Hansen T. C. (1987) Acute phase reaction, heterogeneity and microheterogeneity of serum proteins as non-specific tumor markers in lung cancer. Cancer 60, 1630–1635.
Ros-Bullon, M. R., Sanchez-Pedreno, P. and Martinez-Liarte, J. H. (1999) Serum sialic acid in malignant melanoma patients: An ROC curve analysis. Anticancer Res. 19, 3619–22
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Upadhya, S., Upadhya, S. & Prabhu, K.S. Serum glycoconjugates and ceruloplasmin in cancer of uterine cervix. Indian J Clin Biochem 17, 20–24 (2002). https://doi.org/10.1007/BF02867936
Issue Date:
DOI: https://doi.org/10.1007/BF02867936