Untangling the mystery of Alzheimer’s disease

Understanding molecular mechanisms for novel therapeutic approaches

Abstract

Alzheimer’s disease is one of the most common neurodegenerative disorders amongst the elderly, leading to dementia. Current studies of its molecular basis reveal various factors culminating in the cytotoxic cascade associated with the disease. Progress in understanding these events has led to the identification of novel therapeutic targets. This article is an attempt to understand the global scientific efforts in deciphering the mystery of this disease for a possible cure.

This is a preview of subscription content, log in to check access.

Suggested Reading

  1. [1]

    E R Kandel, J H Schwartz and T M Jessell,Principles of Neural Science, McGraw Hill, 4th ed, pp.1149–1161, 2000.

  2. [2]

    St. P H George-Hyslop, Piecing together Alzheimer’s,Scientific American, Vol. 283, No.6, pp. 52–59, 2000.

    Article  Google Scholar 

  3. [3]

    D J Selkoe, Translating cell biology into therapeutic advances in Alzheimer’s disease,Nature, Vol. 399, A23-A31, 1999.

    Article  Google Scholar 

  4. [4]

    W P Esler and M S Wolfe, A portrait of Alzheimer secretases—new features and familiar faces,Science, Vol. 293, pp. 1449–1454, 2001.

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Sovan Sarkar.

Additional information

All are postgraduate students at School of Biotechnology, Madurai Kamaraj University, Madurai.

Sovan Sarkar’s research interests are gene therapy, apoptosis in cancer treatment and therapeutic approaches for neurodegenerative disorders.

Anupam Choudhury is interested in the study of cytoskeleton and motor proteins, specifically kinesins.

T N Avinash is deeply interested in neuroscience, especially in learning and memory.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sarkar, S., Choudhury, A. & Avinash, T.N. Untangling the mystery of Alzheimer’s disease. Reson 7, 33–45 (2002). https://doi.org/10.1007/BF02867267

Download citation

Keywords

  • Neural Stem Cell
  • Amyloid Plaque
  • Tacrine
  • Baicalein
  • Paired Helical Filament