, Volume 7, Issue 2, pp 33–45 | Cite as

Untangling the mystery of Alzheimer’s disease

Understanding molecular mechanisms for novel therapeutic approaches
  • Sovan SarkarEmail author
  • Anupam Choudhury
  • T N Avinash
General Article


Alzheimer’s disease is one of the most common neurodegenerative disorders amongst the elderly, leading to dementia. Current studies of its molecular basis reveal various factors culminating in the cytotoxic cascade associated with the disease. Progress in understanding these events has led to the identification of novel therapeutic targets. This article is an attempt to understand the global scientific efforts in deciphering the mystery of this disease for a possible cure.


Neural Stem Cell Amyloid Plaque Tacrine Baicalein Paired Helical Filament 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Suggested Reading

  1. [1]
    E R Kandel, J H Schwartz and T M Jessell,Principles of Neural Science, McGraw Hill, 4th ed, pp.1149–1161, 2000.Google Scholar
  2. [2]
    St. P H George-Hyslop, Piecing together Alzheimer’s,Scientific American, Vol. 283, No.6, pp. 52–59, 2000.CrossRefGoogle Scholar
  3. [3]
    D J Selkoe, Translating cell biology into therapeutic advances in Alzheimer’s disease,Nature, Vol. 399, A23-A31, 1999.CrossRefGoogle Scholar
  4. [4]
    W P Esler and M S Wolfe, A portrait of Alzheimer secretases—new features and familiar faces,Science, Vol. 293, pp. 1449–1454, 2001.CrossRefGoogle Scholar

Copyright information

© Indian Academy of Sciences 2002

Authors and Affiliations

  1. 1.II MSc-Biotechnology School of BiotechnologyMadurai Kamaraj UniversityMaduraiIndia

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