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Antimicrobially active substances

V. Antimycotic activity of quaternary ammonium salts

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Abstract

The antimycotic activity of 41 quaternary ammonium compounds was studied. The spectrum of their effect was evaluated in eight microbial strains. Homologues, isomers or close analogues of Septonex, i.e. α-carbetoxypentadecyl-trimethylammonium bromide (XII) were found to be the most active. The presence of an alicyclic or an aromatic ring or of a pyridine residue inhibited antimycotic activity, while substitution of hydrogen by a halogen potentiated it.

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References

  • Foley, E., Lee, S.:Trimethylcetylammonium pentachlorphenate and fatty acids as antifungal agents. J. Am. Pharm. Assoc. Sci. Ed. 36: 198, 1947.

    Article  CAS  Google Scholar 

  • Kull, F. C., Eisman, P. C., Sylwestrowitz, H. D., Mayer, R. L.:Mixtures of quaternary ammonium compounds and long-chain fatty acids as antifungal agents. Appl. Microbiol. 9: 538, 1961.

    PubMed  CAS  Google Scholar 

  • Martin, H. H., Frank, H.:Quantitative Baustein-analyse der Stützmembrane in der Zellwand von Escherichia coli B. Z. Naturforsch. “b” 17: 190, 1962.

    Google Scholar 

  • Novotný, F.:The use of “Septonex” in dermatology. (In Czech) Čs. derm. 42: 115, 1967.

    Google Scholar 

  • Reiss, F., Lustig, B.:Phenols, quaternary ammonium compounds, undecylenic acids and their mixtures and salts. Dermatologica 97: 312, 1948.

    Article  Google Scholar 

  • Znamenáček, K., Janata, V., Bydžovský, V., Horáková, Z.:A new prophylactic against staphylococcal infections of newborn infants. (In Czech) Čs. Pediatr. 17: 177, 1962.

    Google Scholar 

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Authors and Affiliations

  1. Institute of Pharmacy and Biochemistry, Prague 2

    A. Čapek, A. Šimek, D. Němcová & V. Janata

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  1. A. Čapek
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  2. A. Šimek
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  3. D. Němcová
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  4. V. Janata
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Čapek, A., Šimek, A., Němcová, D. et al. Antimicrobially active substances. Folia Microbiol 15, 54–58 (1970). https://doi.org/10.1007/BF02867048

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  • DOI: https://doi.org/10.1007/BF02867048

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