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Biogenesis of peptide antibiotics

I. Dynamics of Antimycin A Biosynthesis byStreptomyces antibioticus NRRL 2838

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Abstract

A simple synthetic medium with glycine,l-tryptophan anddl-alanine was developed for study of antimycin A biogenesis. The strain produced 550 mg of mycelium dry weight and 200 μg of antimycin A per 100 ml of this medium. Intense biosynthesis of antibiotic was initiated in early fermentation and optimum yields were achieved after an additional 96 h incubation. No absolute relationship between growth rate and antimycin A production intensity was found. Biogenesis of antimycin A via tryptophan and formylkynurenine is suggested and similarity in early biogenesis of both antimycin A and actinomycin is considered.

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References

  1. Camiener, G. W., Dietz, A., Argoudelis, A. D., Whitfield, G. B., DeVries, W. H., Large, Ch. M., Smith, Ch. G.:The production of two structurally unrelated antitumor agents, actinomycin and antimycin A by Streptomyces antibioticus cultures. Antimicrob. Agents Ann., Plenum Press N. York, p. 494, 1960.

    Google Scholar 

  2. Katz, E., Weissbach, H.:The biosynthesis of the actinomycins and its relationship to protein synthesis. In: Biogenesis of Antibiotic Substances, Academia Prague, p. 195, 1965.

  3. El-Marsafy, M. K., Řeháček, Z., Abbdel-Gawand, Z.:Electrochromatography of amino acid mixtures in fermentation liquors. Fol. microbiol. 8: 362, 1963.

    Article  CAS  Google Scholar 

  4. Matchett, W. H., DeMoss, J. A.:Physiological channeling of tryptophan in Neurospora crassa. Biochim. biophys. Acta 86: 91, 1964.

    PubMed  CAS  Google Scholar 

  5. Pridham, T. G., Anderson, P., Folye, C., Lindenfelser, L. A., Hesseltine, C. W., Benedict, R. G.:A selection of media for maintenance and taxonomic study of streptomycetes. Antibiotics Ann. 1956/57, p. 947, 1956/1957.

    Google Scholar 

  6. Procházka, Ž.:Indoles. In Lábler, L., Schwarz, V.:Thin layer chromatography. Acad. Sci. Prague, p. 334, 1965.

  7. Řeháček, Z.:Determination of the effectiveness of polyene type antifungal antibiotics in fermentation fluids. Fol. Biol. 4: 254, 1958.

    Google Scholar 

  8. Spies, J. R., Dorris, C., Chambres, C.:Chemical determination of tryptophan. Ann. Chem. 20: 30, 1948.

    Article  CAS  Google Scholar 

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Author notes

  1. L. V. Kannan

    Present address: Antibiotics Division, Central Drug Research Institute, Lucknow, India

Authors and Affiliations

  1. Department of Biogenesis of Natural Products, Institute of Microbiology, Czechoslovak Academy of Sciences, Prague 4

    L. V. Kannan, J. Kozová & Z. Řeháček

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  1. L. V. Kannan
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  2. J. Kozová
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  3. Z. Řeháček
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Kannan, L.V., Kozová, J. & Řeháček, Z. Biogenesis of peptide antibiotics. Folia Microbiol 13, 1–6 (1968). https://doi.org/10.1007/BF02866854

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  • DOI: https://doi.org/10.1007/BF02866854

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