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A sensitive and simplified HPLC analysis for the determination of fluconazol in human plasma

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Abstract

A sensitive and simplified HPLC assay of fluconazol is described. The calibration curve of fluconazol in plasma ranging 0–10 μ g/ml was linear with the correlation coefficients of 0.9900. The limit of detection was 0.3 μ g/ml. The average recovery of the drug was 89.1±9.05%. After oral administration of single dose(150mg) of fluconazol in man, Cmax and Tmax were 3 μg/ml and 4hr., respectively.

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Literature Cited

  1. Troke, P.F., Andrews, R.J., Brammer, K.W., Marriott, M.S. and Richardson, K.: The activity of UK-49858 in several animal models of infection. 1Xth Int. Cong. Int. Soc. Human Anim. Mycol. abstr. R2-7 (1985).

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Authors and Affiliations

  1. Korea Research Institute of Chemical Technology (KRICT), 302-343, Daejon

    Eun J. Kim, Hye S. Lee & Ok P. Zee

  2. Department of Biology, Korea Institute of Technology (KIT), 302-343, Daejon, Korea

    Sung T. Lee

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  1. Eun J. Kim
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  2. Hye S. Lee
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  3. Ok P. Zee
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  4. Sung T. Lee
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Kim, E.J., Lee, H.S., Zee, O.P. et al. A sensitive and simplified HPLC analysis for the determination of fluconazol in human plasma. Arch. Pharm. Res. 11, 250–252 (1988). https://doi.org/10.1007/BF02861318

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  • DOI: https://doi.org/10.1007/BF02861318

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