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Monoamine oxidase-A inhibitors from medicinal plants

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Abstract

Thirty kinds of medicinal plants were screened to examine inhibitory activities on rat brain monoamine oxidase A, using serotonin as a substrate. As active principles, various kinds of stilbenes were isolated from Veratri Rhizoma, Reynoutriae Radix and Rhei undulati Rhizoma, and several kinds of flavonoids from Sophorac Flos, Chrisanthemi Flos andGlycine max. Among the compounds isolated, resveratrol(I) strongly inhibited MAO-A competitively, and its IC50 and Ki values were 2 μM and 2.5 μM, respectively. Inhibitory potencies towards MAO-A of some stilbenes and flavonoids were also compared.

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  1. Natural Products Research Institute, Seoul National University, 110-460, Seoul, Republic of Korea

    Shi Yong Ryu, Yong Nam Han & Byung Hoon Han

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  1. Shi Yong Ryu
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  2. Yong Nam Han
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Ryu, S.Y., Han, Y.N. & Han, B.H. Monoamine oxidase-A inhibitors from medicinal plants. Arch. Pharm. Res. 11, 230–239 (1988). https://doi.org/10.1007/BF02861314

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