Economic Botany

, Volume 37, Issue 1, pp 13–27 | Cite as

Documenting and evaluating herbal remedies

  • Edward M. Croom


Ethnobotanists are frequently involved in the initial documentation of plant remedies used in traditional and popular domestic medicine. To evaluate the safety and efficacy of herbal medicine as actually practiced requires the recording of the variables that can influence the therapeutic outcome. For pharmacological and toxicological testing, the factors controlling the final amount of active compound(s) taken by the patient are especially critical. Since most ethnobotanical studies omit such information, a framework for reporting the major factors is given. Topics discussed, including problems of the literature and suggested formats, are: 1) the plant: common name, scientific name, infraspecific variation, the voucher specimen; 2) preparation of the medicine: plant part, collection, storage, preparation; 3) therapy: general and adjunct, disorder treated, kind of practitioner, dosage regimen, route of administration, response to therapy, status of use; 4) the patient.


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Literature Cited

  1. Abamowicz, M. ed. 1979. Toxic reactions to plant products sold in health food stores. Med. Lett. Drugs Therap. 21: 21–31.Google Scholar
  2. Altschul, Siri von Reis. 1973. Drugs and Foods from Little-Known Plants: Notes in Harvard University Herbaria. Harvard Univ. Press, Cambridge, MA.Google Scholar
  3. Berlin, B., D. E. Breedlove, and P. H. Raven. 1974. Principles of Tzeltal Plant Classification: An Introduction to the Botanical Ethnography of a Mayan-speaking People of the Highland Chiapas. Academic Press, New York.Google Scholar
  4. Betts, T. J. 1965. The conservation of digitalis. Lloydia 28: 181–190.Google Scholar
  5. Bolyard, J. L. 1981. Medicinal Plants and Home Remedies of Appalachia. Thomas, Springfield, IL.Google Scholar
  6. Boyer, J. L. 1978. Hepatic disorders.In Clinical Pharmacology, K. L. Melmon and H. F. Morrelli, ed., p. 388–431. Macmillan, New York.Google Scholar
  7. Brater, D. C, and S. O. Thier. 1978. Renal disorders.In Clinical Pharmacology, K. L. Melmon and H. F. Morrelli, ed., p. 349–387. Macmillan, New York.Google Scholar
  8. Bye, R. A., Jr. 1981. Quelites—Ethnoecology of edible greens—past, present, and future. J. Ethnobiol. 1: 109–123.Google Scholar
  9. Camazine, S., and R. A. Bye. 1980. A study of the medical ethnobotany of the Zuni Indians of New Mexico. J. Ethnopharmacol. 2: 365–388.PubMedGoogle Scholar
  10. Farnsworth, N. R. 1975. The validation of claims for traditional medicines.In Herbal Pharmacology in the People’s Republic of China: a Trip Report of the American Pharmacology Delegation. Nat. Acad. Sci. Washington, DC.Google Scholar
  11. —. 1980. The development of pharmacological and chemical research for application to traditional medicine in developing countries. J. Ethnopharmacol. 2: 173–181.PubMedCrossRefGoogle Scholar
  12. Feinstein, A. R. 1967. Clinical Judgement. Williams & Wilkins, Baltimore, MD.Google Scholar
  13. —. 1977. Clinical Biostatistics. Mosby, St. Louis, MO.Google Scholar
  14. Fernald, M. L. 1950. Gray’s Manual of Botany. 8th ed. American Book, New York.Google Scholar
  15. Flück, H. 1947. The conservation of drugs; chemical and biological aspects. Pharm. J. 159: 375–378.Google Scholar
  16. —. 1954. The influence of the soil on the content of active principles in medicinal plants. J. Pharm. Pharmacol. 6: 153–163.PubMedGoogle Scholar
  17. —. 1955. The influence of climate on the active principles in medicinal plants. J. Pharm. Pharmacol. 7: 361–383.PubMedGoogle Scholar
  18. Ford, R. I., ed. 1978. The Nature and Status of Ethnobotany. Anthropol. Pap. no. 67. Mus. Anthropol., Univ. Michigan, Ann Arbor, MI.Google Scholar
  19. Fosberg, F. R., and M.-H. Sachet. 1965. Manual for Tropical Herbaria. Regnum Veg. Vol. 39. Utrecht.Google Scholar
  20. Gilman, A. G., L. S. Goodman, and A. Gilman, ed. 1980. The Pharmacological Basis of Therapeutics. 6th ed. Macmillan, New York.Google Scholar
  21. Gleason, H. A., and A. Cronquist. 1963. Manual of Vascular Plants of Northeastern United States and Adjacent Canada. Van Nostrand Reinhold, New York.Google Scholar
  22. Gold, C. H. 1980. Acute renal failure from herbal and patent remedies in Blacks. Clin. Nephrol. 14: 128–134.PubMedGoogle Scholar
  23. Goth, A. 1978. Medical Pharmacology. 9th ed. Mosby, St. Louis, MO.Google Scholar
  24. Hand, W. D., ed. 1961. Popular Beliefs and Supersititions from North Carolina.In The Frank C. Brown Collection of North Carolina Folklore. Vol. VI. N. I. White, gen. ed. Duke Univ. Press, Durham, NC.Google Scholar
  25. Hikino, H., C. Yamada, K. Nakamura, H. Sato, Y. Ohizume, and K. Endo. 1977. Changes of alkaloid composition and acute toxicity ofAconitum roots during processing. Yakagaku Zasshi 97: 359–366.Google Scholar
  26. Hill, A. B. 1960. Controlled Clinical Trials. Conference of Council for International Organization of Medical Sciences. Blackwell, Oxford.Google Scholar
  27. —. 1962. Statistical Methods in Clinical and Preventive Medicine. E. & S. Livingston, Edinburgh.Google Scholar
  28. Hirono, I. 1981. Natural carcinogenic products of plant origin. Chemical Rubber Co. Critical Rev. Toxicol. 8: 235–277.CrossRefGoogle Scholar
  29. Holmgren, P. K., W. Keuken, and E. K. Schofield. 1981. Index Herbariorum: Pt. 1 The Herbaria of the World. 7th ed. Regnum Veg., Vol. 106. Utrecht.Google Scholar
  30. Huxtable, R. J. 1980. Herbal teas and toxins: novel aspects of pyrrolizidine poisoning in the United States. Perspect. Biol. Med. 24: 1–14.PubMedGoogle Scholar
  31. Jacobs, M. L., and H. M. Burlage. 1958. Index of Plants of North Carolina with Reputed Medicinal Uses. Burlage, Chapel Hill, NC.Google Scholar
  32. Knowler, W. C, D. J. Pettitt, P. J. Savage, and P. H. Bennett. 1981. Diabetes incidence in Pima Indians: contributions of obesity and parental diabetes. Amer. J. Epidemiol. 173: 144–156.Google Scholar
  33. LaBarre, W. 1959. Materia medica of the Aymara, Lake Titicaca Plateau, Bolivia. Webbia 15: 47–94.Google Scholar
  34. Lewis, W. H., and M. P. F. Elvin-Lewis. 1979. Systematic botany and medicine.In Systematic Botany, Plant Utilization and Biosphere Conservation, I. Hedberg, ed. Almquist & Wiksell, Uppsala.Google Scholar
  35. Malone, M. H. 1981. The pharmacological evaluation of natural products—general and specific approaches to screening ethnopharmaceuticals.In Onderzoek naar Biologische Aktiviteit van Natuurstoffen. Proceedings van het 7de Symposium voor Farmacognosie, C. Violon, V. Maes, and A. Vercruysse, ed., p. 3–28. Vrije Universiteit Brussel, Brussels, Belgium.Google Scholar
  36. Melmon, K. L., and H. F. Morrelli, ed. 1978. Clinical Pharmacology. Macmillian, New York.Google Scholar
  37. Mika, E. S. 1962. Selected aspects on the effect of environment and heredity on the chemical composition of seed plants. Lloydia 25: 291–295.Google Scholar
  38. Moerman, D. E. 1979. Symbols and selectivity: a statistical analysis of Native American ethnobotany. J. Ethnopharmacol. 1: 111–119.PubMedCrossRefGoogle Scholar
  39. Mooney, J. 1886. The sacred formulas of the Cherokees. p. 301–397.In Bur. Amer. Ethnol. 7th Annual Report. Smithsonian, Washington, DC.Google Scholar
  40. Mooney, J., and F. M. Olbrechts. 1932. The Swimmer Manuscript, Cherokee Sacred Formulas and Medicinal Prescriptions. Smithsonian, Bur. Amer. Ethnol. Bull., 99.Google Scholar
  41. Morton, J. F. 1974. Folk Remedies of the Low Country. Seemann Pub., Miami, FL.Google Scholar
  42. —. 1977. Major Medicinal Plants: Botany, Culture, Uses. Thomas, Springfield, IL.Google Scholar
  43. Penso, G. 1980. The role of WHO in the selection and characterization of medicinal plants (vegetable drugs). J. Ethnopharmacol. 2: 183–188.PubMedCrossRefGoogle Scholar
  44. Radford, A. E., H. E. Ahles, and C. R. Bell. 1968. Manual of the Vascular Flora of the Carolinas. Univ. North Carolina Press, Chapel Hill, NC.Google Scholar
  45. —, W. C. Dickison, J. R. Massey, and C. R. Bell. 1974. Vascular Plant Systematics. Harper and Row, New York.Google Scholar
  46. Rao, R. R. 1981. Ethnobotany of Meghalaya: Medicinal plants used by Khasi and Garo tribes Econ. Bot. 35: 4–9.Google Scholar
  47. Reis, Siri von, and F. J. Lipp, Jr. 1982. New Plant Sources for Drugs and Foods from the New York Botanical Garden Herbarium. Harvard Univ. Press, Cambridge, MA.Google Scholar
  48. Riegelman, R. K. 1981. The hidden holes in the history. Postgrad. Med. 70: 40–45.PubMedGoogle Scholar
  49. Robinson, T. 1974. Metabolism and function of alkaloids in plants. Science 184: 430–435.PubMedCrossRefGoogle Scholar
  50. Salemink, C. A. 1980. Problems involved in structure determination of active principles of plants used in traditional medicine: extraction, separation and determination of characteristics of active principles. J. Ethnopharmacol. 2: 135–143.PubMedCrossRefGoogle Scholar
  51. Savage, P. J., L. J. Bennion, E. V. Flock, M. Nagulesparan, D. Mott, J. Ross, R. H. Unger, and P. H. Bennett. 1979. Diet-induced improvement of abnormalities in insulin and glucagon secretion and in insulin receptor binding in diabetes mellitus. J. Clinical Endrocrinol. Metab. 48: 999–1007.CrossRefGoogle Scholar
  52. Schröder, H. 1965. Untersuchungen über Veränderungen des Morphingehalts reifender Mohnkapseln. Die Pharmazie 20: 169–171.Google Scholar
  53. Schultes, R. E. 1962. The role of the ethnobotanist in the search for new medicinal plants. Lloydia 25: 257–266.Google Scholar
  54. Schwartz, D., R. Flamant, and J. Lellouch. 1980. Clinical Trials. M. J. R. Healy, translator. Academic Press, London.Google Scholar
  55. Segelman, A. B., F. P. Segelman, J. Karliner, and R. D. Sofia. 1976. Sassafras and herb tea, potential health hazards. J. Amer. Med. Assoc. 236: 477.CrossRefGoogle Scholar
  56. Siegel, R. K. 1976. Herbal intoxication: psychoactive effects from herbal cigarettes, tea, and capsules. J. Amer. Med. Assoc. 236: 473–476.CrossRefGoogle Scholar
  57. Smith, C. E., Jr. 1971. Preparing Herbarium Specimens of Vascular Plants. USDA Agric. Inform. Bull. No. 348.Google Scholar
  58. Speck, F. G. 1937. Catawba medicines and curative practices. Publ. Philadelphia Anthropol. Soc. 1: 179–197.Google Scholar
  59. —. 1944. Catawba herbals and curative practices. J. Amer. Folklore 52: 37–50.CrossRefGoogle Scholar
  60. Sturtevant, W. C. 1955. The Mikasuki Seminole: Medical Beliefs and Practices. Yale Univ., New Haven, CT. Available from Univ. Microfilms, Ann Arbor, MI. Pub. No. 67-11,355.Google Scholar
  61. Sullivan, J. B., B. H. Rumack, H. Thomas, Jr., R. G. Peterson, and P. Bryson. 1979. Pennyroyal oil poisoning and hepatotoxicity. J. Amer. Med. Assoc. 242: 2873–2874.CrossRefGoogle Scholar
  62. Swanton, J. R. 1946. The Indians of the Southeastern United States. Smithsonian Institution, Bur. Amer. Ethnol. Bull. 137.Google Scholar
  63. Taylor, L. A. 1940. Plants Used as Curatives by Certain Southeastern Tribes. Harvard Botanical Museum, Cambridge, MA. AMS Press Reprint, New York, 1978.Google Scholar
  64. Tetenyi, P. 1970. Infraspecific Chemical Taxa of Medicinal Plants. Chemical Publishing, New York.Google Scholar
  65. Tyler, V. E., L. R. Brady, and J. E. Robbers. 1976. Pharmacognosy. 7th ed. Lea and Febiger, Philadelphia, PA.Google Scholar
  66. Vogel, V. J. 1970. American Indian Medicine. Univ. Oklahoma Press, Norman, OK.Google Scholar
  67. Waller, G. R., and E. K. Nowacki. 1978. Alkaloid Biology and Metabolism in Plants. Plenum, New York.Google Scholar
  68. Webster’s Third New International Dictionary of the English Language Unabridged. 1976. Merriam, Springfield, MA.Google Scholar

Copyright information

© The New York Botanical Garden 1983

Authors and Affiliations

  • Edward M. Croom
    • 1
  1. 1.Department of BotanyNorth Carolina State UniversityRaleigh

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