Summary
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1.
Tetrandrine was found to decrease the contractility, ±dT/dtmax and automaticity and prolong the functional refractory period of cat papillary muscle, but it exerted no influence on its excitability.
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2.
The above results are in accordance with those we obtained previously in guinea pig atrium.
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3.
The negative inotropic and automaticitic effects indicate that tetrandrine might be a calcium influx blocker like verapamil.
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References
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29: 43, 1966
1979
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Weixing, Y., Dachao, F. & Mingxing, J. Studies on the calcium antagonistic action of tetrandrine: II. Effects of tetrandrine on cat papillary muscle. Acta Academiae Medicinae Wuhan 2, 51–54 (1982). https://doi.org/10.1007/BF02858851
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DOI: https://doi.org/10.1007/BF02858851