Abstract
The hydrazine derivative2 has been utilized for the synthesis of three different fused 1,2,4-triazolo [4,3-a] pyrimidine derivatives4, 5 &6 and a tetrazolo[1,5-a] pyrimidine derivative7. Reaction of2 with the chalcone analogue 2-thenylidene-2′-acetothienone, gave the pyrazoline derivative8.
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Monge Vega, A., Aldana, I., Rabbani, M.M. and Fernandez-Alvarez, E.: The synthesis of 11H-1,2,4-triazolo[4,3-b]pyridazino[4,5-b]indoles, 11H-tetrazolo[4,5-b]pyridazino[4,5-a]indoles.J. Heterocycl. Chem. 17, 77 (1980).
Shishoo, C.J., Devani, M.B., Ullas, G.V., Ananthan, S. and Bhadti, V.S.: Synthesis of 5H-triazolo[1,5-d]-and 5H-tertrazolo[1,5-d]thieno[3, 2-f]-1,4-diazepin-6(7H)-ones,J. Heterocyl. Chem. 25, 615 (1988).
Moustafa, M.A.A., Ismaiel, A.M., Eisa, H.M. and El-Emam, A.: Synthesis of 1-phenyl-1H-tetrazolo[4,5-d]tetrazole and 5-aryl-1-(4-bromophenyl)-1,2,4-triazolo[4,3-d]tetrazoles,J. Chin. Chem. Soc. 37, (1990) (in press).
Terán, C., Raviña, E., Santana, L., Garcia-Dominguez, N., Garcia-Mera, G., Fontenla, J.A., Orallo, F. and Calleja, J.M.: Synthesis and hypotensive activity of 3-hydrazino-cycloalkyl[1,2-c]pyridazines and their derivatives,Arch. Pharm. (Weinheim) 322, 331 (1989).
Ichiba, M. and Senga, K.: Reaction of 6-arylidene-hydrazino-1,3-dimethyl uracils with thionyl chloride leading to purine, thiazolo[4,5-d]pyrimidine, pyrimido[4,5-e] [1,3,4]thiadiazine, pyrazolo[3,4, d]pyrimidine, and [1,2,3]thiazolo[4,5-d]pyrimidine derivatives,J. Heterocycl. Chem. 22, 381 (1985).
El-Kerdawy, M.M., Ismaiel, A.M., Gineinah, M.M. and Glennon, R.A.: A convenient synthesis of 3-aryl-1,2,4-triazolo [4,3-c] quinazolines.J. Heterocycl. Chem. 27, 497 (1990).
Bartsch, H. and Erker, T.: Studies on the chemistry O,N-and S,N-containing heterocycles 4[1]. Investigations on the nucleophilic substitution of activated 1,5-benzothiazepines.J. Heterocycl. Chem. 25, 1399 (1988).
Hans Joerg, S., and Wolfgang, P.: Pteridines LXI. Synthesis and properties of thiolumazines.Chem. Ber. 107, 3377 (1974).
Marvel, C.S., Quinn, J.M. and Showell, J.S.: Copolymerization of conjugated unsaturated carbonyl systems containing thiophene unitsJ. Org. Chem. 18, 1730 (1953).
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Moustafa, M.A., Gineinah, M.M., Bayomi, S.M. et al. Investigation of the reaction of 6-amino-3-methyl-4-oxo-3,4-dihydro-2-pyrimidinylhydrazine. Arch. Pharm. Res. 13, 347–350 (1990). https://doi.org/10.1007/BF02858171
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DOI: https://doi.org/10.1007/BF02858171