Skip to main content
SpringerLink
Log in

Preparation of substained-release microspheres of phenylpropanolamine HCl and their release characteristics

  • Original Articles
  • Published:
Archives of Pharmacal Research Aims and scope Submit manuscript

Abstract

Sustained release microspheres containing phenylpropanolamine HCl (PPA) were prepared with acrylic polymer (Eudragit RL/RS) sand hydroxypropylmethylcellulose phthalate (HPMCP) using a emulsion-solvent evaporation method. Magnesium stearate was used a smoothing agent for preparation of microspheres. The microspheres obtained were very spherical and free-flowing particles. Scanning electron microscopy showed that microspheres have a smooth surface and a sponge-like internal structure.

The dissolution rate of PPA from the microspheres was dependent on the pH of dissolution media. PPA showed faster release in pH 1.2 solution than in pH 7.4 solution due to the solubility of PPA. Therefore we prepared new microspheres containing 5% (w/v) HPMCP in order to control the release of PPA. The release rate of PPA from these new microspheres was similar in pH 1.2 and pH 7.4 solution.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. Martin, A., Swarbrick, J. and Cammarata, A.: Physical Pharmacy 3rd ed., Lea and Febiger, Philadelphia, p. 547 (1983).

    Google Scholar 

  2. Kitajima, M., Yamaguchi, T., Kondo, A. and Muroya, N.: Encapsulation method,U. S. Patent 3,691,090 (1972).

  3. Kitajima, M., Kondo, A., Morishita, M. and Abe, J.: Process for preparing a microcapsule,U. S. Patent 3,714,065 (1973).

    Google Scholar 

  4. Fukushima, M., Inaba, Y., Kobari, S. and Morishita, M.: Process for preparing microcapsules,U.S. Patent 3,891,570 (1975).

    Google Scholar 

  5. Morishita, M., Inaba, Y. and Fukushima, M.et al.: Preparation of microcapsule,U.S. Patent 3,943,063 (1976).

  6. Information Sheets “Eudragit RL and RS”, Rohm pharma.

  7. Kawata, J., Nakamura, M., Goto, S. and Aoyama, T.: Preparation and dissolution pattern of Eudragit RS microcapsules containing ketoprofen,Chem. Pharm. Bull. 34, 2618 (1986).

    PubMed  CAS  Google Scholar 

  8. American Society of Hospital Pharmacists: Drug Information, p. 658 (1988).

  9. Revision Committee: The United States Pharmacopeia 21th ed., The United States Pharmacopeial Convention, Inc., p. 1243 (1985).

  10. Kriesel, K. and Metha, S.P.:U.S. Patent 4,340,882 (1985).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. College of Pharmacy, Seoul National University, 151-742, Seoul, Korea

    Chong-Kook Kim, Kyung-Mi Lee, Sung-Joo Hwang & Yong-Sang Yoon

Authors
  1. Chong-Kook Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kyung-Mi Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sung-Joo Hwang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yong-Sang Yoon
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kim, CK., Lee, KM., Hwang, SJ. et al. Preparation of substained-release microspheres of phenylpropanolamine HCl and their release characteristics. Arch. Pharm. Res. 13, 293–297 (1990). https://doi.org/10.1007/BF02858161

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02858161

Keywords

Search

Navigation