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A study of stabilization effect of α-tocopherol incorporated into liposomal phospholipid membrane

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Abstract

The stabilization effect of α-tocopherol incorporated into liposomal phospholipid membrane was investigated by fluorospectrophotometry and UV-visible spectrophotometry. The release of entraped carboxyfluorescein from liposomes was markedly retarded by the presence of α-tocopherol in the bilayer of liposomal phospholipid membrane relative to cholesterol-containing liposomes and pure phospholipid liposomes. α-tocopherol-containing liposomes prolonged the oxidation of liposomes-embedded heme as an oxygen carrier. The oxidation index of α-tocopherol-containing liposomes was lower than those of cholesterol-containing liposomes and pure phospholipid liposomes. Thus α-tocopherol-containing liposomes may be useful for the carrier systems of nutrients and drugs to phospholipid bilayer and stabilized liposomes.

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Authors and Affiliations

  1. Department of Food and Nutrition, Pusan Women's University, 607-737, Pusan, Korea

    Song-Ja Bac

  2. College of Pharmacy, Pusan National University, 609-735, Pusan, Korea

    Nam-Hong Kim

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  1. Song-Ja Bac
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Bac, SJ., Kim, NH. A study of stabilization effect of α-tocopherol incorporated into liposomal phospholipid membrane. Arch. Pharm. Res. 13, 64–68 (1990). https://doi.org/10.1007/BF02857836

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  • DOI: https://doi.org/10.1007/BF02857836

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