Abstract
The present study was undertaken to determine the inhibitory effects of cholane compounds, ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) on the development of morphine-induced tolerance and physical dependence, and also to determine the hepatic glutathione contents. UDCA and CDCA inhibited the development of morphine-induced tolerance and physical dependence significantly. UDCA inhibited the hepatic glutathione decrease induced by morphine multiple injections, while this effect was not observed in CDCA treated mice. It was throught that the inhibitiory effects of hepatic glutathione decrease in morphine-treated mice by UDCA and CDCA showed a tendency of inhibitory effects of development of morphine tolerance and dependence.
Similar content being viewed by others
Literature Cited
Nishida, F., Yamano, S. and Taki, S.: Inhibition of guinea pig liver naloxone reductase by steroids, Abstracts, The 104th Annual Meeting of Pharmaceutical Society of Japan, p. 537 (1985).
Yamano, S., Nishida, F. and Toki, S.: Guineapig liver morphine 6-dehydrogenase as a naloxone reductase,Biochem. Pharmacol.,35, 431 (1986).
Bacharch, W.H. and Hoffmann, A.E.: Ursodeoxycholic acid in the teatment of cholesterol cholethiasis,Dig. Sci.,27, 737 (1982).
Nagamatsu, K., Kido, Y., Terao, T., Ishida, T. and Toki, S.: Protective effects of sulfhydryl compounds on acute tocixity of morphine,Life Sci.,30, 1121 (1982).
Nagamatsu, K., Kido, Y., Terao, T., Ishida, T. and Toki, S.: Studies on the mechanism of covalent binding of morphine metabolites to proteins in mouse,Drug. Metabol. Dispos.,11, 190 (1983).
McCartney, M.A.: Effect of glutathione depletion on morphine tocixity in mice,Biochem. Pharmacol.,38, 207 (1989).
Kaneto, H., Kasaka, N. and Hirota, N.: Timing of cycloheximide administration and inhibition of the development of analgesic tolerance to morphine,Life Sci.,31, 2351 (1982).
D'Amour, F.E. and Smith, D.L.: A method for determining loss of pain sensation,J. Pharmacol. Exp. Ther.,72, 74 (1942).
Kim, H.S., Oh, K.W. Park, W.K., Choi, J.W. and Bae, D.S.: Effect of panax ginseng on the development of morphine induced tolerance and dependence (VI). On the oral administration of ginseng ther fraction and saponons.Arch. Pharm. Res.,10, 188 (1987).
Kim, H.S., Jang, C.G. and Lee, M.K.: Antinarcotic Effects of the Standardized Ginseng Extract G115 on Morphine, Planta Medica (1989), in press.
Tagashira, E. and Dewey, W.L.: Pharmacological effects of T'S and blue on narcotic-induced antinociception and physical dependence on morphine. Abstracts, The 16th Symposium of Drug Metabolism, Phamacology and Toxicology in Japan, p. 165 (1984).
Ellman, G.L.: Tissue sulfhydryl group.Arch. Biochem. Biophys.,82, 70 (1959).
Kim, H.S., Oh, K.W., Park, W.K., Toki, S. and Yamano, S.: Effects of panax ginseng on the development of morphine tolerance and dependence.Kor. J. Ginseng Sci.,11, 182 (1987).
Kim, H.S. and Oh, S.K.: Effects of panax ginseng on the development of morphine induced tolerance and dependence (I).Yakhak Hoeji,29, 27 (1985).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kim, HS., Lee, YE., Oh, KW. et al. Effects of cholane compounds on the development of morphine tolerance. Arch. Pharm. Res. 13, 38–42 (1990). https://doi.org/10.1007/BF02857832
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02857832