Abstract
Reaction of propane-1,3-sultone with amines gave N-substituted aminosulphonic acids2a−i. Dehydration of2a−c with POCl3 gave the corresponding sultams3a−c. Propane-1,3-sultone1 reacted with tertury amines to give the betaiene salts4–11. 2,4-Dimethyl-1,3-butadiene-1,4-sultone12 condensed with amines to give N-substituted-2,4-dimethyl-1,3-butadiene-1,4-sultams13a and13b. The reaction of3a, 13a with hydrazine hydrate gave acid hydrazides3d or13c. Compounds3d, 13c reacted with isocyanates to yield urea derivatives14a−c, 15a−c.
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Ismail, I.I. Synthesis of sulphonic acids and sultam derivatives. Arch. Pharm. Res. 13, 1–4 (1990). https://doi.org/10.1007/BF02857824
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DOI: https://doi.org/10.1007/BF02857824