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Hydrolysis of esters and amides of 20R- and 20S-dihydroprednisolonic acid in rat serum and liver homogenate

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Abstract

The hydrolysis rates of ester and amide derivatives of 20-dihydropredmisolonic acid were measured in rat serum and liver homogenate. The hydrolysis rate of the esters in serum was found to be faster than that in liver homogenate on the basis of blood volume and liver weight, while the amide derivatives showed much slower change. And it is also found that the size of substituents at C-21 and C-20 configuration expressed considerable effects on the hydrolysis rate of these derivatives.

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Authors and Affiliations

  1. Dept. Biol. Sci. Eng., KAIST, 130-650, Seoul, Korea

    Kue Jeong Yeon & Si Myung Byun

  2. College of Pharmacy, Florida AM Univ., 32307, FL, USA

    Henry J. Lee

  3. Dept. Pharmacy, KangWeon Nat’l. Univ., 200-701, Chuncheon, Korea

    Sean Hyang Lee & Hyun Pyo Kim

Authors
  1. Kue Jeong Yeon
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  2. Si Myung Byun
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  3. Henry J. Lee
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  4. Sean Hyang Lee
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  5. Hyun Pyo Kim
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Yeon, K.J., Byun, S.M., Lee, H.J. et al. Hydrolysis of esters and amides of 20R- and 20S-dihydroprednisolonic acid in rat serum and liver homogenate. Arch. Pharm. Res. 12, 68–72 (1989). https://doi.org/10.1007/BF02857725

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  • DOI: https://doi.org/10.1007/BF02857725

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